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Discovery of De Novo Macrocyclic Peptides by Messenger RNA Display

التفاصيل البيبلوغرافية
العنوان: Discovery of De Novo Macrocyclic Peptides by Messenger RNA Display
المؤلفون: Hayden Peacock, Hiroaki Suga
المصدر: Trends in pharmacological sciences. 42(5)
سنة النشر: 2021
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, chemistry.chemical_classification, Messenger RNA, Drug discovery, Ribosomal RNA, Toxicology, Amino acid, Protein–protein interaction, 03 medical and health sciences, Macrocyclic peptide, 030104 developmental biology, 0302 clinical medicine, chemistry, Biochemistry, Peptide Library, mRNA display, Humans, RNA, Messenger, Amino Acids, Peptides, Ribosomes, 030217 neurology & neurosurgery
الوصف: Macrocyclic peptides are a promising class of compounds that can often engage challenging therapeutic targets. Display technologies, such as mRNA display, allow for the efficient discovery of macrocyclic peptides. This article reviews the current approaches for generating macrocyclic peptide libraries using mRNA display and highlights some recent examples of ribosomal incorporation of nonproteinogenic amino acids into macrocyclic peptides.
تدمد: 1873-3735
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5d559b81fb7dfaa080384dca3699e1
https://pubmed.ncbi.nlm.nih.gov/33771353
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....7f5d559b81fb7dfaa080384dca3699e1
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18733735