Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii )–amyloid-β
| العنوان: | Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn( |
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| المؤلفون: | Jiyeon Han, Min Hee Park, Hee Kyung Jin, Nahye Park, Mi Hee Lim, Eunju Nam, Yelim Yi, Jae-sung Bae |
| المصدر: | Chemical Communications. 55:5847-5850 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Amyloid β, 010405 organic chemistry, Stereochemistry, Phenanthroline, Metals and Alloys, General Chemistry, 010402 general chemistry, 01 natural sciences, Small molecule, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Materials Chemistry, Ceramics and Composites, medicine, Acid sphingomyelinase, medicine.drug |
| الوصف: | We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(ii)-bound amyloid-β [Zn(ii)-Aβ], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(ii) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(ii)-Aβ (phen, 1, and 2), or both (3). |
| تدمد: | 1364-548X 1359-7345 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffa1fdc539cdcd91a4a011aa9512add https://doi.org/10.1039/c9cc01005j |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....7ffa1fdc539cdcd91a4a011aa9512add |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1364548X 13597345 |
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