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Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus

التفاصيل البيبلوغرافية
العنوان: Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and Reduced Tacrolimus
المؤلفون: Shun Nishioka, Masato Fujisawa, Takahito Endo, Takeshi Ishimura, Satoshi Ogawa, Naoki Yokoyama
المصدر: Annals of Transplantation
بيانات النشر: International Scientific Information, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Adult, Graft Rejection, Male, medicine.medical_specialty, Urology, Kidney, Tacrolimus, Fibrosis, Biopsy, medicine, Humans, Everolimus, PI3K/AKT/mTOR pathway, Kidney transplantation, Transplantation, Original Paper, medicine.diagnostic_test, business.industry, TOR Serine-Threonine Kinases, General Medicine, Middle Aged, medicine.disease, Allografts, Immunohistochemistry, Kidney Transplantation, Pathophysiology, Transplant Recipients, medicine.anatomical_structure, Female, business, Immunosuppressive Agents, medicine.drug
الوصف: BACKGROUND Although renoprotective effects of everolimus (EVR) in kidney transplantation (KTx) have been widely reported, its pathophysiological mechanism remains unclear. MATERIAL AND METHODS We compared changes in eGFR (ΔGFR, ml/min/1.73 m²) and the ratio of the fibrotic area in biopsy specimens (ΔFI,%) from 3 months to 3 years after KTx between the EVR+ group (EVR addition and Tac reduction early after KTx, n=32), and the EVR- group (normal Tac without EVR, n=28). We also immunohistochemically evaluated mTOR-related protein expression. RESULTS ΔGFR and ΔFI in the EVR+ vs. EVR- groups were -0.27±6.8 vs. -9.8±12.8 (p
وصف الملف: application/pdf
اللغة: English
تدمد: 2329-0358
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804a6f0a0886c3b403f633085d5b1db6
https://hdl.handle.net/20.500.14094/90007857
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....804a6f0a0886c3b403f633085d5b1db6
قاعدة البيانات: OpenAIRE
الوصف
تدمد:23290358