Decreased CDX2 Expression Adversely Effect On Prognosis Of Patients With Colorectal Cancer
| العنوان: | Decreased CDX2 Expression Adversely Effect On Prognosis Of Patients With Colorectal Cancer |
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| المؤلفون: | Adile Ferda Dağli, Gokhan Artas, Ibrahim Hanifi Ozercan, Gulistan Turken, Burcu Sarikaya, Muhammet Calik, Ilknur Calik |
| المصدر: | Dicle Medical Journal, Vol 47, Iss 1, Pp 57-65 (2020) Volume: 47, Issue: 1 57-65 Dicle Tıp Dergisi |
| بيانات النشر: | Dicle University Medical School, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Multivariate analysis, Colorectal cancer, overall survival, lcsh:Medicine, colorectal cancer, Health Care Sciences and Services, Internal medicine, medicine, Colorectal cancer,CDX2,prognosis,overall survival, Sağlık Bilimleri ve Hizmetleri, Stage (cooking), disease-free survival, Univariate analysis, lcsh:R5-920, Proportional hazards model, business.industry, cdx2, Hazard ratio, lcsh:R, Retrospective cohort study, medicine.disease, Confidence interval, digestive system diseases, embryonic structures, prognosis, business, lcsh:Medicine (General) |
| الوصف: | Objective: Since colorectal cancers (CRC) are tumors with heterogeneous biological behavior, prediction of their prognosis remains challenging. Caudal-related homeobox gene 2 (CDX2), which has important roles in the development and maintenance of intestines, is thought to have tumor suppressing effect on CRCs. The aim of this study was to investigate the prognostic significance of decreased-CDX2 expression. Method: This retrospective study included 224 patients diagnosed with CRC between 2009 and 2014. Paraffinized blocks of these patients were stained with CDX2 immunohistochemically and evaluated semiquantitatively. Results: Only 35 (15.6%) of 224 patients had low-CDX2 expression. Decrease in CDX2 expression was closely associated with classical prognostic parameters such as histopathologic type, histologic grade, lymph node metastasis, distant metastasis, and TNM stage. Patients with decreased-CDX2 expression had more lymph node metastasis (p=0.013) and advanced TNM stage (p=0.004) than those without decreased-expression. The mean survival was 53.0±0.89 months. Cox regression analysis showed that decreased-CDX2 expression was significantly related with overall survival (Univariate analysis; hazard ratio: 0.09, 95% confidence interval: 0.05-0.16; p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1308-9889 1300-2945 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805fc0a6ac6d33d3651b84171e0fb249 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....805fc0a6ac6d33d3651b84171e0fb249 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13089889 13002945 |
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