Levels of tacrolimus after treatment for chronic hepatitis C with direct antiviral agents in solid organ transplant recipients
| العنوان: | Levels of tacrolimus after treatment for chronic hepatitis C with direct antiviral agents in solid organ transplant recipients |
|---|---|
| المؤلفون: | Sara Ibáñez-García, Francisco Jesús Fernández-Avilés Díaz, Juan Fernández-Yáñez, Xandra García-González, Eduardo Zataraín-Nicolás, María Sanjurjo Sáez, Maria Luisa Rodríguez-Ferrero |
| المصدر: | International Journal of Clinical Pharmacy. 43:731-736 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Hepatitis C virus, Pharmaceutical Science, Renal function, Pharmacy, Toxicology, medicine.disease_cause, Antiviral Agents, 030226 pharmacology & pharmacy, Gastroenterology, Tacrolimus, Organ transplantation, 03 medical and health sciences, 0302 clinical medicine, Maintenance therapy, Internal medicine, Humans, Medicine, Pharmacology (medical), 030212 general & internal medicine, Pharmacology, Kidney, business.industry, Hepatitis C, Chronic, Hepatitis C, Kidney Transplantation, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, business, Solid organ transplantation, Immunosuppressive Agents, After treatment |
| الوصف: | Background and objective The main objective was to evaluate the impact of Hepatitis C Virus treatment with direct-acting antiviral agents on tacrolimus blood levels in recipients of kidney and heart allografts. Method We analysed Hepatitis C Virus infected adult patients who received tacrolimus as immunosuppressive maintenance therapy and received direct-acting antiviral agents treatment in a tertiary hospital with solid transplant multidisciplinary program in Madrid, Spain. Liver and renal function, tacrolimus dose and blood levels were analysed before and 12 weeks after the end of treatment. Results We identified 7 kidney and 2 heart transplant recipients. All patients achieved sustained virologic response at 24 weeks. At week 12 after treatment, all liver functionality tests improved significantly with no significant changes in renal function. A decrease in the tacrolimus blood level/dose ratio for every patient was observed (370.04 ± 253.93 vs. 186.44 ± 123.74 ng/mL per mg/kg; p |
| تدمد: | 2210-7711 2210-7703 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80708bb1d35b1ac6b6c4d61d502864c1 https://doi.org/10.1007/s11096-020-01162-6 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....80708bb1d35b1ac6b6c4d61d502864c1 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 22107711 22107703 |
|---|