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Long-term prognoses and outcomes of axillary lymph node recurrence in 2,578 sentinel lymph node-negative patients for whom axillary lymph node dissection was omitted: results from one Japanese hospital

التفاصيل البيبلوغرافية
العنوان: Long-term prognoses and outcomes of axillary lymph node recurrence in 2,578 sentinel lymph node-negative patients for whom axillary lymph node dissection was omitted: results from one Japanese hospital
المؤلفون: Akiko Ogiya, Hidetomo Morizono, Takehiko Sakai, Takuji Iwase, Kiyomi Kimura, Yumi Miyagi, Eri Nakashima, Kotaro Iijima, Masujiro Makita, Rie Horii, Futoshi Akiyama
المصدر: Breast cancer (Tokyo, Japan). 23(2)
سنة النشر: 2014
مصطلحات موضوعية: Adult, medicine.medical_specialty, Receptor, ErbB-2, Sentinel lymph node, Breast Neoplasms, 030230 surgery, Immunoenzyme Techniques, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Surgical oncology, Biomarkers, Tumor, Medicine, Humans, Pharmacology (medical), Radiology, Nuclear Medicine and imaging, Neoplasm Invasiveness, Lymph node, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, business.industry, Sentinel Lymph Node Biopsy, Incidence, Carcinoma, Ductal, Breast, Axillary Lymph Node Dissection, Cancer, General Medicine, Middle Aged, medicine.disease, Prognosis, Surgery, Survival Rate, medicine.anatomical_structure, Oncology, Receptors, Estrogen, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Axilla, Axillary Dissection, Female, Lymph, Lymph Nodes, Neoplasm Recurrence, Local, business, Receptors, Progesterone, Follow-Up Studies
الوصف: Axillary dissection omission for sentinel lymph node-negative patients has been a practice at Cancer Institute Hospital, Japanese Foundation for Cancer Research since 2003. We examined the long-term results of omission of axillary dissection in sentinel lymph node-negative patients treated at our hospital, as well as their axillary lymph node recurrence characteristics and outcomes.Our study included 2,578 patients with cTis or T1-T3N0M0 primary breast cancer for whom dissection was omitted because they were sentinel lymph node negative. The median observation period was 75 months.In sentinel lymph node-negative patients for whom dissection was omitted, the rates of axillary lymph node recurrence, distant recurrence, and breast cancer mortality were 0.9, 2, and 1 %, respectively. Eighteen patients underwent additional dissection if axillary lymph node recurrence was observed at the first recurrence. Four triple-negative (TN) patients experienced distant recurrence after additional dissection. All four patients were administered anticancer agents after axillary lymph node recurrence and experienced recurrence within 1 year of additional dissection. The axillary lymph node recurrence rate was 0.8 % for luminal and 4.5 % for TN subtypes.The long-term prognoses of patients for whom dissection was omitted owing to negative sentinel lymph node metastases were similar to those reported previously-low recurrence and mortality rates. The frequency of axillary lymph node recurrence and the post-recurrence outcome differed between luminal and TN cases, with recurrence being more frequent in patients with the TN subtype. TN patients also had poorer prognoses, even after receiving additional dissection and anticancer agents after recurrence.
تدمد: 1880-4233
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808379b42ec2ba52bea1798436f9b3cc
https://pubmed.ncbi.nlm.nih.gov/25376341
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....808379b42ec2ba52bea1798436f9b3cc
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18804233