Temporal changes in retinal vascular parameters associated with successful panretinal photocoagulation in proliferative diabetic retinopathy: A prospective clinical interventional study
| العنوان: | Temporal changes in retinal vascular parameters associated with successful panretinal photocoagulation in proliferative diabetic retinopathy: A prospective clinical interventional study |
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| المؤلفون: | Jakob Grauslund, Tunde Peto, Tien Yin Wong, Ryo Kawasaki, Thomas Lee Torp |
| المصدر: | Acta Ophthalmologica Torp, T L, Kawasaki, R, Wong, T Y, Peto, T & Grauslund, J 2017, ' Temporal changes in retinal vascular parameters associated with successful panretinal photocoagulation in proliferative diabetic retinopathy : A prospective clinical interventional study ', Acta Ophthalmologica, pp. 1-6 . https://doi.org/10.1111/aos.13617 Torp, T L, Kawasaki, R, Wong, T Y, Peto, T & Grauslund, J 2018, ' Temporal changes in retinal vascular parameters associated with successful panretinal photocoagulation in proliferative diabetic retinopathy : A prospective clinical interventional study ', Acta Ophthalmologica, vol. 96, no. 4, pp. 405-410 . https://doi.org/10.1111/aos.13617 |
| بيانات النشر: | John Wiley and Sons Inc., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Retinal Vessels/diagnostic imaging, Fluorescein Angiography/methods, Panretinal photocoagulation, Tomography, Optical Coherence/methods, clinical, chemistry.chemical_compound, 0302 clinical medicine, Prospective Studies, Fluorescein Angiography, Laser Coagulation, medicine.diagnostic_test, Retina/pathology, General Medicine, Diabetic retinopathy, Middle Aged, Fluorescein angiography, retinal vessel geometry, computer‐assisted, medicine.anatomical_structure, computer-assisted, Original Article, Female, Tomography, Optical Coherence, Optic disc, proliferative diabetic retinopathy, medicine.medical_specialty, Fundus Oculi, 030209 endocrinology & metabolism, Retina, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Diabetes mellitus, Ophthalmology, Journal Article, medicine, Humans, In patient, Laser Coagulation/methods, Diabetic Retinopathy, business.industry, Retinal Vessels, Retinal, Original Articles, prospective, medicine.disease, Diabetic Retinopathy/diagnosis, panretinal photocoagulation, NAVILAS, Blood pressure, SIVA, chemistry, 030221 ophthalmology & optometry, Optometry, business, Follow-Up Studies |
| الوصف: | PURPOSE: We aimed to investigate changes in retinal vascular geometry over time after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR).METHODS: Thirty-seven eyes with PDR were included. Wide-field fluorescein angiography (Optomap, Optos PLC., Dunfermline, Scotland, UK) was used to diagnose PDR at baseline and to assess activity at follow-up month three and six. At each time-point, a trained grader measured retinal vessel geometry on optic disc (OD) centred images using semiautomated software (SIVA, Singapore I Vessel Assessment, National University of Singapore, Singapore) according to a standardized protocol.RESULTS: At baseline, the mean age and duration of diabetes were 52.8 and 22.3 years, and 65% were male. Mean HbA1c was 69.9 mmol/mol, and blood pressure was 155/84 mmHg. Of the 37 eyes with PDR, eight (22%) eyes had progression at month three and 13 (35%) progressed over six months. Baseline characteristics, including age, sex, duration of diabetes, HbA1c, blood pressure, vessel geometric variables and total amount of laser energy delivered did not differ by progression status. However, compared to patients with progression of PDR, patients with favourable treatment outcome had alterations in the retinal arteriolar structures from baseline to month six (calibre, 154.3 μm versus 159.5 μm, p = 0.04, tortuosity 1.12 versus 1.10, p = 0.04) and in venular structures from baseline to month three (fractal dimension 1.490 versus 1.499, p = 0.04, branching coefficient (BC) 1.32 versus 1.37, p = 0.01).CONCLUSION: In patients with PDR, successful PRP leads to alterations in the retinal vascular structure. However, baseline retinal vascular geometry characteristics did not predict treatment outcome. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1755-3768 1755-375X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8084e485ef65bfbac0bc11846bdaa428 http://europepmc.org/articles/PMC6099241 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8084e485ef65bfbac0bc11846bdaa428 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17553768 1755375X |
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