Na + /H + exchanger 1 inhibition contributes to K562 leukaemic cell differentiation
| العنوان: | Na + /H + exchanger 1 inhibition contributes to K562 leukaemic cell differentiation |
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| المؤلفون: | Qinghua Li, Wei-Na Jin, Guoqiang Chang, Yani Lin, Wei Gao, Lihong Wang, Jian Wang, Tianxiang Pang, Hua-Wen Li |
| المصدر: | Cell Biology International. 36:739-745 |
| بيانات النشر: | Wiley, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Sodium-Hydrogen Exchangers, Myeloid, Intracellular pH, p38 mitogen-activated protein kinases, Cellular differentiation, Guanidines, p38 Mitogen-Activated Protein Kinases, CCAAT-Enhancer-Binding Protein-alpha, medicine, Humans, Sulfones, RNA, Small Interfering, Protein kinase A, Cation Transport Proteins, Leukemia, Sodium-Hydrogen Exchanger 1, biology, Interleukin-8, Cell Differentiation, Cobalt, Cell Biology, General Medicine, Hydrogen-Ion Concentration, Hypoxia (medical), Molecular biology, Cell Hypoxia, Up-Regulation, Cell biology, medicine.anatomical_structure, Mitogen-activated protein kinase, biology.protein, RNA Interference, medicine.symptom, K562 Cells, Signal Transduction, K562 cells |
| الوصف: | The effect of hypoxia on the differentiation of chronic myeloid leukaemic K562 cells were studied, as was the role of the NHE1 (Na+/H+ exchanger 1). Hypoxia induced differentiation of K562 cells as seen by modifications in their morphological features, up-regulation of C/EBPα (CCAAT/enhancer-binding protein α), and marked IL-8 (interleukin-8) release. Inhibition of NHE1 under hypoxia additionally enhanced the level of C/EBPα and further promoted leukaemic cells differentiation. Pharmacological inhibition of p38 MAPK (mitogen-activated protein kinase) also significantly suppressed C/EBPα expression under hypoxia conditions after NHE1 inhibition. These results indicate the enhancement of hypoxia-induced K562 differentiation by NHE1 inhibition, which may be due to up-regulation of C/EBPα via p38 MAPK signalling pathway, which suggests a possible therapeutic target of NHE1 under hypoxia microenvironment in the treatment of leukaemic diseases. |
| تدمد: | 1095-8355 1065-6995 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80994c3535a73c8da972c77b12c62e4b https://doi.org/10.1042/cbi20100919 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....80994c3535a73c8da972c77b12c62e4b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10958355 10656995 |
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