Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex
| العنوان: | Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex |
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| المؤلفون: | Ryozo Oishi, Michihiro Fujiwara, Naoki Uchida, Ryoji Nishimura, Nobuaki Egashira, Ayumi Ishibashi, Kenichi Mishima, Katsunori Iwasaki, Ai Nogami, Kotaro Takasaki |
| المصدر: | Journal of Pharmacological Sciences, Vol 116, Iss 4, Pp 316-320 (2011) |
| بيانات النشر: | Japanese Pharmacological Society, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Pharmacology, Receptor complex, Pentobarbital, Benzodiazepine, medicine.drug_class, business.industry, Kampo, lcsh:RM1-950, Yokukansan, Bicuculline, lcsh:Therapeutics. Pharmacology, Flumazenil, Anesthesia, medicine, Molecular Medicine, Receptor, business, medicine.drug |
| الوصف: | In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABAA – benzodiazepine receptor complex, but not 5-HT1A receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation. Keywords:: sleep, social isolation, Yokukansan |
| تدمد: | 1347-8648 1347-8613 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cae5441f420f9d3be9ec3c889b829c https://doi.org/10.1254/jphs.11079sc |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....80cae5441f420f9d3be9ec3c889b829c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13478648 13478613 |
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