Drug-induced skin toxicity: gaps in preclinical testing cascade as opportunities for complex in vitro models and assays
| العنوان: | Drug-induced skin toxicity: gaps in preclinical testing cascade as opportunities for complex in vitro models and assays |
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| المؤلفون: | Jessica Whritenour, Rhiannon N. Hardwick, Catherine J. Betts, Maike Thamsen, Radhakrishna Sura, Kristin M. Fabre, Elad H. Kaufman |
| المصدر: | Lab on a Chip. 20:199-214 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Drug, Cell type, Drug Industry, media_common.quotation_subject, Biomedical Engineering, Bioengineering, Computational biology, Models, Biological, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Lab-On-A-Chip Devices, Animals, Humans, Medicine, Model development, Skin, 030304 developmental biology, media_common, Pharmaceutical industry, 0303 health sciences, business.industry, General Chemistry, Skin toxicity, Pharmaceutical Preparations, Drug development, Preclinical testing, 030220 oncology & carcinogenesis, business, Phototoxicity |
| الوصف: | Skin is the largest organ of the body and serves as the principle barrier to the environment. Composed of multiple cell types arranged in stratified layers with highly specialized appendages, it serves sensory and immune surveillance roles in addition to its primary mechanical function. Several complex in vitro models of skin (i.e. microphysiological systems (MPS) including but not limited to 3D tissues, organ-on-a-chip, organoids), have been developed and assays validated for regulatory purposes. As such, skin is arguably the most advanced organ with respect to model development and adoption across industries including chemical, cosmetic, and to a somewhat lesser extent, pharmaceutical. Early adoption of complex skin models and associated assays for assessment of irritation and corrosion spurred research into other areas such as sensitization, absorption, phototoxicity, and genotoxicity. Despite such considerable advancements, opportunities remain for immune capabilities, inclusion of appendages such as hair follicles, fluidics, and innervation, among others. Herein, we provide an overview of current complex skin model capabilities and limitations within the drug development scheme, and recommendations for future model development and assay qualification and/or validation with the intent to facilitate wider adoption of use within the pharmaceutical industry. |
| تدمد: | 1473-0189 1473-0197 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80dfc071343eaf8f78bad1d63f87da94 https://doi.org/10.1039/c9lc00519f |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....80dfc071343eaf8f78bad1d63f87da94 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14730189 14730197 |
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