Hypoxia-inducible factor 1-alpha in chronic gastrointestinal ischemia
| العنوان: | Hypoxia-inducible factor 1-alpha in chronic gastrointestinal ischemia |
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| المؤلفون: | Aria Sana, Ernst J. Kuipers, Désirée van Noord, Eric T.T.L. Tjwa, Paul J. van Diest, Katharina Biermann, Leon M G Moons, Petra van der Groep, Jihan Harki |
| المساهمون: | Gastroenterology & Hepatology, Pathology |
| المصدر: | Virchows Archiv, 466, 2, pp. 125-32 Virchows Archives, 466(2), 125. Springer Verlag Virchows Archiv. An International Journal of Pathology, 466(2), 125-132. Springer-Verlag Virchows Archiv, 466, 125-32 |
| بيانات النشر: | Springer-Verlag, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Ischemia, Inflammation, Infectious Colitis, alpha Subunit, Inflammatory bowel disease, Sensitivity and Specificity, Ischemic colitis, Pathology and Forensic Medicine, medicine, Humans, Molecular Biology, Aged, Gastrointestinal tract, business.industry, Cell Biology, General Medicine, Hypoxia (medical), Middle Aged, medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, Inflammatory Bowel Diseases, Immunohistochemistry, Gastrointestinal Tract, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Female, Hypoxia-Inducible Factor 1, medicine.symptom, business |
| الوصف: | Item does not contain fulltext Chronic gastrointestinal ischemia (CGI) is the result of decreased mucosal perfusion. Typical histological characteristics are lacking which hamper its early diagnosis. Hypoxia-inducible factor-1alpha (HIF-1alpha) is expressed under acute hypoxia. We investigated HIF-1alpha expression in chronic ischemic and inflammatory conditions of the human gastrointestinal (GI) tract. Immunohistochemical expression of HIF-1alpha was analyzed in 61 patients, including patients with CGI, Helicobacter pylori gastritis, ischemic colitis (IC), infectious colitis, and inflammatory bowel disease (IBD), and 22 controls. HIF-1alpha expression in >10 % of the cells was regarded as positive staining, and expression |
| وصف الملف: | image/pdf |
| تدمد: | 1432-2307 0945-6317 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812efbddeda1824c9bd687fc7064aea6 https://pure.eur.nl/en/publications/de98053b-348e-4775-a8d5-31f4c232b185 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....812efbddeda1824c9bd687fc7064aea6 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14322307 09456317 |
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