Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicine
| العنوان: | Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicine |
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| المؤلفون: | Bo Huang, Ning Wang, Farhan Chowdhury |
| المصدر: | Cytoskeleton (Hoboken, N.j.) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cytoplasm, substrate stiffness, Cellular differentiation, Cell, Biophysics, Review Article, Biology, Mechanotransduction, Cellular, 03 medical and health sciences, Mechanobiology, immune cells, 0302 clinical medicine, stem cells, Structural Biology, medicine, Humans, Mechanotransduction, Cytoskeleton, Review Articles, 030304 developmental biology, 0303 health sciences, tumor metastasis, Cell Biology, Embryonic stem cell, Chromatin, Cell biology, cell softness, medicine.anatomical_structure, Stress, Mechanical, Stem cell, extracellular vesicles, 030217 neurology & neurosurgery |
| الوصف: | Increasing evidence demonstrates that mechanical forces, in addition to soluble molecules, impact cell and tissue functions in physiology and diseases. How living cells integrate mechanical signals to perform appropriate biological functions is an area of intense investigation. Here, we review the evidence of the central role of cytoskeletal prestress in mechanotransduction and mechanobiology. Elevating cytoskeletal prestress increases cell stiffness and reinforces cell stiffening, facilitates long-range cytoplasmic mechanotransduction via integrins, enables direct chromatin stretching and rapid gene expression, spurs embryonic development and stem cell differentiation, and boosts immune cell activation and killing of tumor cells whereas lowering cytoskeletal prestress maintains embryonic stem cell pluripotency, promotes tumorigenesis and metastasis of stem cell-like malignant tumor-repopulating cells, and elevates drug delivery efficiency of soft-tumor-cell-derived microparticles. The overwhelming evidence suggests that the cytoskeletal prestress is the governing principle and the cellular hallmark in mechanobiology. The application of mechanobiology to medicine (mechanomedicine) is rapidly emerging and may help advance human health and improve diagnostics, treatment, and therapeutics of diseases. This article is protected by copyright. All rights reserved. |
| تدمد: | 1949-3592 1949-3584 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8143b9e1a6b740415db04161b4a60620 https://doi.org/10.1002/cm.21658 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8143b9e1a6b740415db04161b4a60620 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19493592 19493584 |
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