Foci of cyclin A2 interact with actin and RhoA in mitosis
| العنوان: | Foci of cyclin A2 interact with actin and RhoA in mitosis |
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| المؤلفون: | Mariya Georgieva, Shaereh Mashayekhan, Marion Peter, Abdelhalim Loukil, Jean-Marie Blanchard, Fanny Izard, Andrea Parmeggiani |
| المساهمون: | Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Scientific Reports Scientific Reports, Nature Publishing Group, 2016, 6, pp.27215. ⟨10.1038/srep27215⟩ |
| بيانات النشر: | HAL CCSD, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, RHOA, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Cyclin A, Cyclin B, Mitosis, [SDV.CAN]Life Sciences [q-bio]/Cancer, Polo-like kinase, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Article, 03 medical and health sciences, Cell Line, Tumor, Autophagy, Humans, [NLIN.NLIN-CG]Nonlinear Sciences [physics]/Cellular Automata and Lattice Gases [nlin.CG], Biochemical switches in the cell cycle, [NLIN.NLIN-AO]Nonlinear Sciences [physics]/Adaptation and Self-Organizing Systems [nlin.AO], Multidisciplinary, biology, [PHYS.PHYS.PHYS-SOC-PH]Physics [physics]/Physics [physics]/Physics and Society [physics.soc-ph], G1/S transition, [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], Actins, Cell biology, Enzyme Activation, 030104 developmental biology, MCF-7 Cells, biology.protein, Cancer research, rhoA GTP-Binding Protein, Cyclin A2 |
| الوصف: | Cyclin A2 is a key player in the regulation of the cell cycle. Its degradation in mid-mitosis depends primarily on the ubiquitin-proteasome system (UPS), while autophagy also contributes. However, a fraction of cyclin A2 persists beyond metaphase. In this work, we focus on cyclin A2-rich foci detected in mitosis by high resolution imaging and analyse their movements. We demonstrate that cyclin A2 interacts with actin and RhoA during mitosis and that cyclin A2 depletion induces a dramatic decrease in active RhoA in mitosis. Our data suggest cyclin A2 participation in RhoA activation in late mitosis. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8154726f1b5503ab7cdaa6b8e6f5a542 https://hal.archives-ouvertes.fr/hal-01345990/document |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8154726f1b5503ab7cdaa6b8e6f5a542 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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