Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics
| العنوان: | Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics |
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| المؤلفون: | Joshua W. Miller, Ralph Green, Marjorie G. Garrod, Lindsay H. Allen, Mary N. Haan |
| المصدر: | European journal of clinical nutrition |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, Hyperhomocysteinemia, Genotype, Homocysteine, Medicine (miscellaneous), Polymorphism, Single Nucleotide, California, White People, Article, polymorphism, chemistry.chemical_compound, Transcobalamin, Internal medicine, polycyclic compounds, medicine, Humans, Cyanocobalamin, Vitamin B12, Aged, Genetics, Analysis of Variance, Transcobalamins, Nutrition and Dietetics, business.industry, Homozygote, nutritional and metabolic diseases, Hispanic or Latino, vitamin B12, Middle Aged, medicine.disease, Health Surveys, Vitamin B 12, B vitamins, Logistic Models, Endocrinology, chemistry, Hispanic elderly, Vitamin B Complex, Female, business, Methylmalonic Acid |
| الوصف: | Background A common polymorphism, C776G, in the plasma B12 transport protein transcobalamin (TC), encodes for either proline or arginine at codon 259. This polymorphism may affect the affinity of TC for B12 and subsequent delivery of B12 to tissues. Methods TC genotype and its associations with indicators of B12 status, including total B12, holotranscobalamin (holoTC), methylmalonic acid, and homocysteine, were evaluated in a cohort of elderly Latinos (N=554, age 60–93y) from the Sacramento Area Latino Study on Aging (SALSA). Results The distribution of TC genotypes was 41.3% homozygous reference (776CC) and 11.6% homozygous variant (776GG). No differences between the homozygous genotypes were observed in total B12, holoTC, methylmalonic acid, or homocysteine. The holoTC/total B12 ratio was lower in the 776GG group compared with the 776CC group (p=0.04). Significant interactions of TC genotype with total B12 (p=0.04) and with holoTC (p≤0.03) were observed such that mean homocysteine concentrations and the odds ratios for hyperhomocysteinemia (>13 µmol/L) were higher in the 776CC subjects compared with all carriers of the G allele (776CG and 776GG combined) when total B12 ( |
| تدمد: | 1476-5640 0954-3007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8171fdcf9985201781966c9a905bda85 https://doi.org/10.1038/ejcn.2010.20 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8171fdcf9985201781966c9a905bda85 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765640 09543007 |
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