Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank
| العنوان: | Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank |
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| المؤلفون: | Gunilla Hedlin, Omer Kalayci, Antoine Deschildre, Heather J. Zar, Ioana Agache, Alan Kaplan, Alexander G. Mathioudakis, Paraskevi Xepapadaki, Timothy J. Craig, Despo Ierodiakonou, Francine M. Ducharme, Ioanna Tsiligianni, Marina Mitrogiorgou, Gary W.K. Wong, Gioulinta S. Alimani, Wojciech Feleszko, Matteo Bonini, Georgios A. Mathioudakis, Paulo Márcio Pitrez, Zuzana Diamant, Jose A. Castro-Rodriguez, Antonio Nieto Garcia, Mário Morais-Almeida, Peter N. Le Souëf, David Price, Petr Pohunek, Paolo Maria Matricardi, Jonathan Grigg, Mika J. Mäkelä, Elham Hossny, Robert F. Lemanske, Aziz Sheikh, Clare S. Murray, Timothy Felton, Effie Papageorgiou, Stephen Turner, Karthik Nagaraju, Nikolaos G. Papadopoulos, Apostolos Beloukas, Michael Miligkos, Tonya A. Winders, Helena Pité, James E. Gern, Wanda Phipatanakul, Giuseppe De Carlo, Leonard B. Bacharier, Adnan Custovic, Cristina Boccabella, Graham Roberts, Susanne J. H. Vijverberg, Andrew Bentley, Tuomas Jartti |
| المساهمون: | HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, Pulmonology, AII - Inflammatory diseases, APH - Personalized Medicine |
| المصدر: | BMJ Open r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Mathioudakis, A G, Miligkos, M, Boccabella, C, Alimani, G S, Custovic, A, Deschildre, A, Ducharme, F M, Kalayci, O, Murray, C, Garcia, A N, Phipatanakul, W, Price, D, Sheikh, A, Agache, I O, Bacharier, L, Beloukas, A, Bentley, A, Bonini, M, Castro-Rodriguez, J A, De Carlo, G, Craig, T, Diamant, Z, Feleszko, W, Felton, T, Gern, J E, Grigg, J, Hedlin, G, Hossny, E M, Ierodiakonou, D, Jartti, T, Kaplan, A, Lemanske, R F, Le Souëf, P N, Mäkelä, M J, Mathioudakis, G A, Matricardi, P, Mitrogiorgou, M, Morais-Almeida, M, Nagaraju, K, Papageorgiou, E, Pité, H, Pitrez, P M C, Pohunek, P, Roberts, G, Tsiligianni, I, Turner, S, Vijverberg, S, Winders, T A, Wong, G W K, Xepapadaki, P, Zar, H J & Papadopoulos, N G 2021, ' Management of asthma in childhood : Study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank ', BMJ Open, vol. 11, no. 7, e048338, pp. e048338 . https://doi.org/10.1136/bmjopen-2020-048338 BMJ Open, 11(7):e048338. BMJ PUBLISHING GROUP Mathioudakis, A G, Miligkos, M, Boccabella, C, Alimani, G S, Custovic, A, Deschildre, A, Ducharme, F M, Kalayci, O, Murray, C, Garcia, A N, Phipatanakul, W, Sheikh, A, Agache, I O, Bacharier, L, Beloukas, A, Bentley, A, Bonini, M, Castro-Rodriguez, J A, De Carlo, G, Craig, T, Diamant, Z, Feleszko, W, Felton, T, Gern, J E, Grigg, J, Hedlin, G, Hossny, E M, Ierodiakonou, D, Jartti, T, Kaplan, A, Lemanske, R F, Le Souëf, P N, Mäkelä, M J, Mathioudakis, G A, Matricardi, P, Mitrogiorgou, M, Morais-Almeida, M, Nagaraju, K, Papageorgiou, E, Pité, H, Pitrez, P M C, Pohunek, P, Roberts, G, Tsiligianni, I, Vijverberg, S, Winders, T A, Wong, G W, Xepapadaki, P, Zar, H J & Papadopoulos, N G 2021, ' Management of asthma in childhood : study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank ', BMJ Open, vol. 11, no. 7, pp. e048338 . https://doi.org/10.1136/bmjopen-2020-048338 BMJ Open, Vol 11, Iss 7 (2021) BMJ open, 11(7):e048338. BMJ Publishing Group |
| بيانات النشر: | BMJ PUBLISHING GROUP, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Thoracic medicine, asthma, paediatric thoracic medicine, paediatrics, thoracic medicine, thoracic medicine, engineering.material, paediatrics, 03 medical and health sciences, 0302 clinical medicine, Administrative support, Bias, 3123 Gynaecology and paediatrics, Medicine, In real life, Humans, 030212 general & internal medicine, INHALER, Child, Asthma, Protocol (science), business.industry, General Medicine, asthma, medicine.disease, 3. Good health, respiratory tract diseases, Hospitalization, Paediatric asthma, 030228 respiratory system, Research centre, Research Design, Family medicine, paediatric thoracic medicine, engineering, business, Pearl, Systematic Reviews as Topic |
| الوصف: | IntroductionClinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on paediatric asthma maintenance management and an SR of treatments for acute asthma attacks in children, requiring an emergency presentation with/without hospital admission will be conducted.Methods and analysisStandard methodology recommended by Cochrane will be followed. Maintenance pharmacotherapy of childhood asthma will be evaluated in an overview of SRs published after 2005 and including clinical trials or real-life studies. For evaluating pharmacotherapy of acute asthma attacks leading to an emergency presentation with/without hospital admission, we opted to conduct de novo synthesis in the absence of adequate up-to-date published SRs. For the SR of acute asthma pharmacotherapy, we will consider eligible SRs, clinical trials or real-life studies without time restrictions. Our evidence updates will be based on broad searches of Pubmed/Medline and the Cochrane Library. We will use A MeaSurement Tool to Assess systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence AssessmeNt Tool to evaluate the methodological quality of SRs, controlled clinical trials and real-life studies, respectively.Next, we will further assess interventions for acute severe asthma attacks with positive clinical results in meta-analyses. We will include both controlled clinical trials and observational studies and will assess their quality using the previously mentioned tools. We will employ random effect models for conducting meta-analyses, and Grading of Recommendations Assessment, Development and Evaluation methodology to assess certainty in the body of evidence.Ethics and disseminationEthics approval is not required for SRs. Our findings will be published in peer reviewed journals and will inform clinical recommendations being developed by the PeARL Think Tank.PROSPERO registration numbersCRD42020132990, CRD42020171624. |
| وصف الملف: | application/pdf; text |
| تدمد: | 2044-6055 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f589b9b8bbc9cd67582d2237d1d76f https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=14772 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....81f589b9b8bbc9cd67582d2237d1d76f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20446055 |
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