Validation of a spatial agent-based model for Taenia solium transmission ('CystiAgent') against a large prospective trial of control strategies in northern Peru
| العنوان: | Validation of a spatial agent-based model for Taenia solium transmission ('CystiAgent') against a large prospective trial of control strategies in northern Peru |
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| المؤلفون: | Ian W Pray, Francesco Pizzitutti, Gabrielle Bonnet, Eloy Gonzales-Gustavson, Wayne Wakeland, William K Pan, William E Lambert, Armando E Gonzalez, Hector H Garcia, Seth E O'Neal, Cysticercosis Working Group in Peru. |
| المصدر: | PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009885 (2021) PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021) PLoS Neglected Tropical Diseases PLOS Neglected Tropical Diseases |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Rural Population, Swine, Physiology, Eggs, RC955-962, Psychological intervention, Binomials, Polynomials, Geographical locations, law.invention, Medical Conditions, sensitivity analysis, law, Pig Models, Animal Products, Reproductive Physiology, Zoonoses, Arctic medicine. Tropical medicine, Peru, Taenia solium, Medicine and Health Sciences, Taeniasis, Pork, spatiotemporal analysis, Prospective Studies, travel, parasite control, Agent-based model, Mammals, Swine Diseases, adult, parasite transmission, Eukaryota, neurocysticercosis, Cysticercosis, Agriculture, Animal Models, simulation, medicine.drug_formulation_ingredient, Transmission (mechanics), Infectious Diseases, Experimental Organism Systems, Helminth Infections, Vertebrates, Physical Sciences, Female, Public aspects of medicine, RA1-1270, Research Article, Neglected Tropical Diseases, prospective study, taeniasis, Meat, Biology, Research and Analysis Methods, World health, Article, foraging, Environmental health, parasitic diseases, medicine, Parasitic Diseases, Animals, Humans, controlled study, human, Nutrition, Spatial Analysis, nonhuman, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, South America, medicine.disease, Tropical Diseases, calibration, Diet, enzyme linked immunosorbent assay, Algebra, Prospective trial, Food, sensitivity and specificity, validation process, Amniotes, randomized controlled trial, Animal Studies, Epidemiological Models, People and places, Zoology, Mathematics |
| الوصف: | Background The pork tapeworm (Taenia solium) is a parasitic helminth that imposes a major health and economic burden on poor rural populations around the world. As recognized by the World Health Organization, a key barrier for achieving control of T. solium is the lack of an accurate and validated simulation model with which to study transmission and evaluate available control and elimination strategies. CystiAgent is a spatially-explicit agent based model for T. solium that is unique among T. solium models in its ability to represent key spatial and environmental features of transmission and simulate spatially targeted interventions, such as ring strategy. Methods/Principal findings We validated CystiAgent against results from the Ring Strategy Trial (RST)–a large cluster-randomized trial conducted in northern Peru that evaluated six unique interventions for T. solium control in 23 villages. For the validation, each intervention strategy was replicated in CystiAgent, and the simulated prevalences of human taeniasis, porcine cysticercosis, and porcine seroincidence were compared against prevalence estimates from the trial. Results showed that CystiAgent produced declines in transmission in response to each of the six intervention strategies, but overestimated the effect of interventions in the majority of villages; simulated prevalences for human taenasis and porcine cysticercosis at the end of the trial were a median of 0.53 and 5.0 percentages points less than prevalence observed at the end of the trial, respectively. Conclusions/Significance The validation of CystiAgent represented an important step towards developing an accurate and reliable T. solium transmission model that can be deployed to fill critical gaps in our understanding of T. solium transmission and control. To improve model accuracy, future versions would benefit from improved data on pig immunity and resistance, field effectiveness of anti-helminthic treatment, and factors driving spatial clustering of T. solium infections including dispersion and contact with T. solium eggs in the environment. Author summary Neurocysticercosis, caused by the ingestion of Taenia solium eggs, is a major cause of human epilepsy around the world. A wide spectrum of tools to fight T. solium is are now available and include antiparasitic treatment for pigs and humans, porcine vaccines, and sanitation improvements; however, the ideal combination of interventions applied to populations to maximize effectiveness and feasibility is not known. Transmission models are one tool that can be used to compare and evaluate different intervention strategies, but no currently available T. solium models have been tested for accuracy. In this research, we validated our model (“CystiAgent”) by comparing simulations of the model to the results of a large-scale trial testing a variety of T. solium control interventions. The model was calibrated using observed epidemiological data from these villages and evaluated for its ability to reproduce the effect of T. solium control interventions. The validation showed that the model was able to reproduce the baseline levels of disease, but generally overestimated the effect that each intervention would have on transmission. These results will allow us to identify limitations of the current model to improve future versions, and represent a step forward in the creation of a tool to design and evaluate future programs to control and eliminate T. solium. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1935-2735 1935-2727 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823d8bba56ca0dd9c749a35e012de582 https://doaj.org/article/405e5200606c4635be7c93c90cdb786a |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....823d8bba56ca0dd9c749a35e012de582 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19352735 19352727 |
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