Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans
| العنوان: | Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans |
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| المؤلفون: | Huseyin Simavli, Teresa C. Chen, Michael McClurkin, Eric Shieh, Christian Que, Ali Riza Cenk Celebi, Edem Tsikata, Ramon Lee, Elli A. Park, Rong Guo, Hussein Antar, Tobias Elze, Johannes F. de Boer, Jing Zhang, Alice Chandra Verticchio Vercellin, Madeline Freeman |
| المساهمون: | Amsterdam Neuroscience - Brain Imaging, Biophotonics and Medical Imaging, LaserLaB - Biophotonics and Microscopy, Acibadem University Dspace |
| المصدر: | Celebi, A R C, Park, E A, Vercellin, A C V, Tsikata, E, Lee, R, Shieh, E, Antar, H, Freeman, M, Zhang, J, Que, C, Simavli, H, McClurkin, M, Guo, R, Elze, T, De Boer, J F & Chen, T C 2021, ' Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans ', Translational Vision Science and Technology, vol. 10, no. 6, 28, pp. 1-13 . https://doi.org/10.1167/TVST.10.6.28 Translational Vision Science & Technology Translational Vision Science and Technology, 10(6):28, 1-13. Association for Research in Vision and Ophthalmology |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Retinal Ganglion Cells, medicine.medical_specialty, genetic structures, Optic Disk, Biomedical Engineering, Nerve fiber layer, Glaucoma, Article, Spectral domain optical coherence tomography, chemistry.chemical_compound, symbols.namesake, Nerve Fibers, Optical coherence tomography, Ophthalmology, medicine, Humans, Mathematics, medicine.diagnostic_test, Structure-function relationship, Retinal, medicine.disease, Minimum distance band, Pearson product-moment correlation coefficient, eye diseases, medicine.anatomical_structure, Retinal nerve fiber layer, chemistry, Neuroretinal rim, symbols, Tomography, sense organs, Glaucoma, Open-Angle, Tomography, Optical Coherence, Volume (compression) |
| الوصف: | Purpose To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans. Methods Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thickness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch's membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength. Results The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statistically significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20). Conclusions Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness. Translational relevance This paper illustrates the potential for 3D OCT algorithms to improve in vivo imaging in glaucoma. |
| اللغة: | English |
| تدمد: | 2164-2591 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a907ca2c089b240d57087b20086c91 https://hdl.handle.net/1871.1/4caf4b3a-f423-4383-986f-91625c811b3b |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....82a907ca2c089b240d57087b20086c91 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21642591 |
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