Detection of antibodies to L1, L2, and E4 proteins of human papillomavirus types 6, 11, and 16 by ELISA using synthetic peptides
| العنوان: | Detection of antibodies to L1, L2, and E4 proteins of human papillomavirus types 6, 11, and 16 by ELISA using synthetic peptides |
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| المؤلفون: | J M Afoutou, D. Leboulleux, C Mougin, P. Coursaget, V Mayelo, P. Le Cann, M C Legrand, C Calvet, A.M. Coll-Seck, M Chabaud |
| المصدر: | Journal of Medical Virology. 45:410-414 |
| بيانات النشر: | Wiley, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, Molecular Sequence Data, Enzyme-Linked Immunosorbent Assay, Biology, Antibodies, Viral, Epitope, Virus, Serology, Epitopes, Viral Proteins, Capsid, Antigen, Virology, Prevalence, medicine, Humans, Amino Acid Sequence, Child, Antigens, Viral, Papillomaviridae, Peptide sequence, Aged, Papillomavirus Infections, HPV infection, virus diseases, Oncogene Proteins, Viral, Middle Aged, Protein-Tyrosine Kinases, medicine.disease, Peptide Fragments, female genital diseases and pregnancy complications, Tumor Virus Infections, Infectious Diseases, Case-Control Studies, Child, Preschool, Immunology, biology.protein, Capsid Proteins, Female, Viral disease, Antibody |
| الوصف: | Antibodies against eight synthetic peptides spanning different epitopes located on L1, L2, and E4 proteins of human papillomavirus (HPV) types 16, 6, and 11 were examined in sera from 73 women infected by HPV and from 139 healthy controls. Only three of these peptides were reactive. Two located on proteins L2 and E4 of HPV 16 seem type specific since antibodies to these peptides were detected, respectively, in 21% and 15% of the HPV 16 infected patients and in 2.5% and none of women infected by other HPVs. The third peptide located on the L1 protein of HPV 6 bears a common epitope since antibodies to this peptide were detected not only in 85% of women infected by HPV 6 or 11, but also in 82% of women infected by other HPVs, and in 74% and 71% of the control groups (10-12-year-old children and adults, respectively). In conclusion, none of the peptides investigated seems useful to develop ELISAs for serological diagnosis of HPV infection. |
| تدمد: | 1096-9071 0146-6615 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e35de6c8feb783ac1bb6cd706330ba https://doi.org/10.1002/jmv.1890450410 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....82e35de6c8feb783ac1bb6cd706330ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969071 01466615 |
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