Radiotherapy in Case of Locally Advanced Prostate Cancer: Long-Term follow-up in 223 Patients
| العنوان: | Radiotherapy in Case of Locally Advanced Prostate Cancer: Long-Term follow-up in 223 Patients |
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| المؤلفون: | F. Trevisan, Alessandro Antonelli, Sergio Cosciani Cunico, Nicola Bastiani, Stefano Maria Magrini, Claudio Simeone, Luca Giovanessi |
| المصدر: | Urologia Journal. 79:53-57 |
| بيانات النشر: | SAGE Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Oncology, Biochemical recurrence, medicine.medical_specialty, medicine.medical_treatment, Rectum, Prostate cancer, Prostate, Internal medicine, medicine, Humans, External beam radiotherapy, Prostatectomy, business.industry, Prostatic Neoplasms, General Medicine, Prostate-Specific Antigen, medicine.disease, Radiation therapy, Prostate-specific antigen, Treatment Outcome, medicine.anatomical_structure, Radiology, business, Follow-Up Studies |
| الوصف: | Aim of the study To evaluate the long-term follow-up in patients undergoing external beam radiotherapy for locally advanced prostate cancer. Patients and methods From November 1999 to January 2007, 223 patients with a histologic diagnosis (204 transperineal needle biopsies; 19 trans-urethral prostatic resections) of locally advanced prostate cancer underwent external beam radiotherapy; of these patients, 151 were T3a (extracapsular extension) and 72 were T3b (involvement of seminal vesicles); the extracapsular extension was demonstrated using pelvic RMN or transrectal ultrasound, while the presence of distant and lymph node metastases was excluded using TC total body or bone scan. PSA value at diagnosis was 29.1 ng/mL (0.4-379 ng/mL). Radiotherapy was used on prostate and seminal vesicles in 201 patients (141 T3a; 60 T3b) while in 22 patients (10 T3a; 12 T3b) it was extended to the pelvis. Biochemical recurrence was defined using ASTRO definition (three consecutive PSA rises after PSA nadir); no patients underwent control prostate needle biopsy for problems of interpretation related to postactinic tissue changes. All complications were recorded and analyzed using Radiation Morbidity Scoring Criteria (RTOG). Results At a mean 55-month follow-up, of the 223 patients treated, 26 have escaped controls, 168 are alive (141 disease-free; 27 with recurrent disease) and 29 died; of this group, 11 patients died from clinical progression, while in the others the cause was not related to the prostatic problem; only one patient died from iatrogenic problems. Hormone treatment was conducted in different ways (neoadjuvant, adjuvant, concurrent to radiotherapy or in association) considering patients' characteristics. Most common complications involved rectum and bladder. Conclusions Radiotherapy is a viable and safe method in the treatment of locally advanced prostate cancer; however, it is essential the role of hormone therapy. |
| تدمد: | 1724-6075 0391-5603 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834b6cd774f4dd42411525abba0fd1ad https://doi.org/10.5301/ru.2012.9740 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....834b6cd774f4dd42411525abba0fd1ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17246075 03915603 |
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