Fear of dying and inflammation following acute coronary syndrome
| العنوان: | Fear of dying and inflammation following acute coronary syndrome |
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| المؤلفون: | Andrew Steptoe, Gerard J. Molloy, Gemma Randall, Juan Carlos Kaski, Nadine Messerli-Bürgy, Anna Wikman, Linda Perkins-Porras |
| المصدر: | Steptoe, Andrew; Molloy, Gerry J.; Messerli-Bürgy, Nadine; Wikman, Anna; Randall, Gemma; Perkins-Porras, Linda; Kaski, Juan Carlos (2011). Fear of dying and inflammation following acute coronary syndrome. European Heart Journal, 32(19), pp. 2405-2411. Oxford: Oxford University Press 10.1093/eurheartj/ehr132 <http://dx.doi.org/10.1093/eurheartj/ehr132> |
| بيانات النشر: | Oxford University Press (OUP), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Cortisol secretion, Acute coronary syndrome, medicine.medical_specialty, Attitude to Death, Hydrocortisone, Internal medicine, medicine, Humans, Heart rate variability, Myocardial infarction, Acute Coronary Syndrome, Saliva, Psychiatry, Depression (differential diagnoses), Aged, biology, Tumor Necrosis Factor-alpha, business.industry, C-reactive protein, Arrhythmias, Cardiac, Fear, Middle Aged, medicine.disease, Distress, biology.protein, Female, Cardiology and Cardiovascular Medicine, business, Stress, Psychological, medicine.drug |
| الوصف: | Aims Many patients are afraid of dying during acute coronary syndrome (ACS), but the origins and biological correlates of these emotional responses are poorly understood. This study evaluated the prevalence of fear of dying, associations with inflammatory responses during ACS, and later heart rate variability (HRV) and cortisol secretion. Methods and results Two hundred and eight patients admitted with clinically verified ACS rated their fear of dying on interview in hospital. Plasma tumour necrosis factor (TNF)α was recorded on admission, and HRV and salivary cortisol were assessed 3 weeks later. Intense distress and fear of dying was experienced by 21.7%, with moderate levels in 66.1% patients. Fear of dying was more common in younger, lower socioeconomic status, and unmarried patients. It was positively associated with plasma TNFα on admission after controlling for sociodemographic factors, clinical risk, and pain intensity (adjusted odds = 4.67, 95% C.I. 1.66–12.65). TNFα was associated with reduced HRV 3 weeks later, adjusting for clinical and sociodemographic factors and medication ( P = 0.019), while fear of dying was associated with reduced cortisol output ( P = 0.004). Conclusions Intense distress and fear of dying and heightened inflammation may be related manifestations of an acute biobehavioural response to severe cardiac injury, and have implications for prognostically significant biological risk processes. |
| وصف الملف: | application/pdf |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835ae1ea498e22413eb834308905e5a9 https://doi.org/10.1093/eurheartj/ehr132 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....835ae1ea498e22413eb834308905e5a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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