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Evaluation Of Erythrocyte Membrane Fatty Acid Compositions in Compliance with IL-6 Levels in COVID-19 Patients

التفاصيل البيبلوغرافية
العنوان: Evaluation Of Erythrocyte Membrane Fatty Acid Compositions in Compliance with IL-6 Levels in COVID-19 Patients
المؤلفون: Erdim Sertoglu, Cigdem Yucel, Ahmet Rıfat Balık, Cantürk Taşçı, Sedat Bilge, Meryem Sebla Ertuğrul, Namık Kemal Nazaroğlu, Taner Ozgurtas
المصدر: Nutrition (Burbank, Los Angeles County, Calif.)
بيانات النشر: Published by Elsevier Inc., 2021.
سنة النشر: 2021
مصطلحات موضوعية: IL-6, Nutrition and Dietetics, Interleukin-6, Endocrinology, Diabetes and Metabolism, Erythrocyte Membrane, Fatty Acids, Article, AA/EPA ratio, Fatty Acids, Omega-3, cytokine storm, PUFAs, Humans, ω-6/ω-3 ratio, Covid-19
الوصف: The cytokine storm presented in the hyperimmune response is related to poor prognosis in people with COVID-19. Interleukin-6 (IL-6) is one of the most prominent cytokines, especially on mucosal surfaces during infection, causing the cytokine storm. Polyunsaturated fatty acids (PUFAs) are the precursors of eicosanoids, which play critical roles in immune regulation and inflammation. The balance between ω-3 and ω-6 levels in the cell membrane has a critical role in regulating the equilibrium between proinflammatory and antiinflammatory processes and inducing IL-6 production. The present study focused on inflammatory and antiinflammatory mechanisms in COVID-19 over PUFAs and on relating their levels with disease prognosis and severity.A total of 106 participants were included in the study. They were divided into three groups according to IL-6 level- 1:35 pg/mL, 2: between 35 and 300 pg/mL, and 3:300 pg/mL. Erythrocyte membrane PUFA compositions were analyzed by group.Levels of γ-linolenic acid and ω-6/ω-3 ratios were significantly increased in all comparison groups (P0.05). Total ω-6 and the ratio of arachidonic acid to eicosopentaenoic acid showed a statistically significant difference only between groups 1 and 3 (P0.05). There was a moderately negative correlation between total ω-3 and IL-6 and procalcitonin. There were positive correlations with ω-6/ω-3 ratio inflammatory markers, and the total ω-6 index also showed a moderately positive correlation with IL-6, procalcitonin, and D-dimer levels.The ratio of arachidonic acid to eicosopentaenoic acid, and ω-3 PUFAs, can be systemic signs of poor prognosis, increased lung damage, and high mortality in COVID-19, together with IL-6.
اللغة: English
تدمد: 1873-1244
0899-9007
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8368f9e2eaaae1c73c15538400a0d0e4
http://europepmc.org/articles/PMC8710241
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....8368f9e2eaaae1c73c15538400a0d0e4
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18731244
08999007