Trajectory of blood pressure, body mass index, cholesterol and incident dementia: systematic review
| العنوان: | Trajectory of blood pressure, body mass index, cholesterol and incident dementia: systematic review |
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| المؤلفون: | Ruth Peters, Jean Peters, Kaarin J. Anstey, Andrew Booth |
| المصدر: | The British Journal of Psychiatry. 216:16-28 |
| بيانات النشر: | Royal College of Psychiatrists, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Gerontology, Population ageing, business.industry, Blood Pressure, PsycINFO, medicine.disease, Body Mass Index, 03 medical and health sciences, Psychiatry and Mental health, Cholesterol, 0302 clinical medicine, Blood pressure, Risk Factors, Humans, Medicine, Dementia, Cognitive Dysfunction, Observational study, 030212 general & internal medicine, Risk factor, Cognitive decline, business, Body mass index, 030217 neurology & neurosurgery |
| الوصف: | BackgroundThe global ageing population and the long prodromal period for the development of cognitive decline and dementia brings a need to understand the antecedents of both successful and impaired cognitive ageing. It is increasingly apparent that the trajectory of risk-factor change, as well as the level of the risk factor, may be associated with an increased or decreased risk of cognitive decline or dementia.AimsOur aim was to summarise the published evidence and to generate hypotheses related to risk-factor trajectories and risk of incident cognitive decline or dementia.MethodWe collated data from longitudinal observational studies relating to trajectory of blood pressure, obesity and cholesterol and later cognitive decline or dementia using standard systematic review methodology. The databases MEDLINE, Embase and PsycINFO were searched from inception to 26 April 2018.ResultsThirteen articles were retained for inclusion. Analytical methods varied. Our summary of the current evidence base suggests that first body mass index and then blood pressure rises and then falls more steeply in those who go on to develop dementia. The evidence for cholesterol was less consistent.ConclusionBased on our review we present the hypothesis that weight falls around 10 years and blood pressure around 5 years before diagnosis. Confirmatory work is required. However, characterisation of risk according to combinations and patterns of risk factors may ultimately be integrated into the assessments used to identify those at risk of receiving a diagnosis of cognitive decline or dementia in late life. |
| تدمد: | 1472-1465 0007-1250 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838aeb97d6437eed369edce48f9a08d0 https://doi.org/10.1192/bjp.2019.156 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....838aeb97d6437eed369edce48f9a08d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14721465 00071250 |
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