Is There One Key Step in the Metastatic Cascade?
| العنوان: | Is There One Key Step in the Metastatic Cascade? |
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| المؤلفون: | Jean-Pascal Capp, Frédéric Thomas, Antoine M. Dujon, Beata Ujvari, Pascal Pujol, Robert A. Gatenby, Catherine Alix-Panabières, Joel S. Brown |
| المساهمون: | Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Deakin University, Burwood, Australia, Deakin University [Burwood], Toulouse Biotechnology Institute (TBI), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), H. Lee Moffitt Cancer Center and Research Institute, Unité d'Oncogénétique, CRLCC Val d'Aurelle - Paul Lamarque, University of Tasmania [Hobart, Australia] (UTAS), Université de Montpellier (UM), MAVA foundation, Innovation program under the Marie Sklodowska-Curie grant765492, Fondation ARC pour la Recherche sur le Cancer, Institut National du Cancer (INCA) France, ANR-18-CE35-0009,TRANSCAN,ECOLOGIE ET EVOLUTION DES CANCERS TRANSMISSIBLES(2018), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | Cancers Cancers, MDPI, 2021, 13 (15), ⟨10.3390/cancers13153693⟩ Cancers; Volume 13; Issue 15; Pages: 3693 Cancers, 2021, 13 (15), ⟨10.3390/cancers13153693⟩ Cancers, Vol 13, Iss 3693, p 3693 (2021) |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, circulating tumor cells, Metastasis, Critical phase, 03 medical and health sciences, 0302 clinical medicine, Circulating tumor cell, Breast cancer, Internal medicine, medicine, metastasis, metastatic process, RC254-282, Metastatic cascade, Drake equation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, medicine.disease, 3. Good health, 030104 developmental biology, Critical parameter, 030220 oncology & carcinogenesis |
| الوصف: | International audience; The majority of cancer-related deaths are the result of metastases (i.e., dissemination and establishment of tumor cells at distant sites from the origin), which develop through a multi-step process classically termed the metastatic cascade. The respective contributions of each step to the metastatic process are well described but are also currently not completely understood. Is there, for example, a critical phase that disproportionately affects the probability of the development of metastases in individual patients? Here, we address this question using a modified Drake equation, initially formulated by the astrophysicist Frank Drake to estimate the probability of the emergence of intelligent civilizations in the Milky Way. Using simulations based on realistic parameter values obtained from the literature for breast cancer, we examine, under the linear progression hypothesis, the contribution of each component of the metastatic cascade. Simulations demonstrate that the most critical parameter governing the formation of clinical metastases is the survival duration of circulating tumor cells (CTCs). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8406ca7fccdb5f9798fad19cebc2203a https://hal.inrae.fr/hal-03442172/document |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8406ca7fccdb5f9798fad19cebc2203a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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