Antiretroviral Therapy for HIV-Associated Cutaneous Kaposi's Sarcoma: Clinical, HIV-Related, and Sociodemographic Predictors of Outcome
| العنوان: | Antiretroviral Therapy for HIV-Associated Cutaneous Kaposi's Sarcoma: Clinical, HIV-Related, and Sociodemographic Predictors of Outcome |
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| المؤلفون: | John T. West, Salum J. Lidenge, Owen Ngalamika, Charles E. Wood, Sody Munsaka |
| المصدر: | AIDS Research and Human Retroviruses |
| بيانات النشر: | Mary Ann Liebert, Inc., publishers, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, Immunology, antiretroviral therapy, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Malignancy, outcomes, Outcomes Research, 03 medical and health sciences, 0302 clinical medicine, Virology, Internal medicine, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Kaposi's sarcoma, Sarcoma, Kaposi, business.industry, food and beverages, virus diseases, HIV, Viral Load, medicine.disease, Antiretroviral therapy, CD4 Lymphocyte Count, 030104 developmental biology, Infectious Diseases, predictors, Sarcoma, business |
| الوصف: | Kaposi's sarcoma (KS) is an AIDS-defining malignancy that can improve or worsen with antiretroviral therapy (ART). We aimed at identifying clinical, HIV-related, and sociodemographic factors associated with either progression or nonprogression (regression or stable disease) of ART-treated HIV-associated KS in patients with limited cutaneous disease. We conducted a prospective cohort study of ART-treated HIV-associated KS cases. Clinical, HIV-related, and sociodemographic variables were collected at baseline, and patients were followed up to determine treatment outcomes. Cox regression, linear mixed effects model, and Spearman's rank correlation were used for analysis. Half (50%) of the study participants had KS regression or stable disease, whereas the other half (50%) had disease progression during the treatment and follow-up period. Among the data analyzed, presence of KS nodules at baseline (hazard ratio = 5.47; 95% confidence interval = 1.32–22.65; p = .02) was an independent predictor of poor treatment outcome. Progressors and nonprogressors were indistinguishable in the changes they experienced in the HIV plasma viral load and CD4 counts as a result of ART. Even when cutaneous presentation is limited, the presence of nodular morphotype KS lesions should be considered an indicator for combined ART plus chemotherapy. Temporal trends in CD4 counts and HIV viral loads did not correlate with treatment outcome in ART-treated HIV-associated KS. |
| اللغة: | English |
| تدمد: | 1931-8405 0889-2229 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847936c9c72cc48811bc986bdd5225d0 http://europepmc.org/articles/PMC8112720 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....847936c9c72cc48811bc986bdd5225d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19318405 08892229 |
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