Piezo2 is the principal mechanotransduction channel for proprioception
العنوان: | Piezo2 is the principal mechanotransduction channel for proprioception |
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المؤلفون: | Joriene C. de Nooij, Viktor Lukacs, Katherine A. Wilkinson, Allain G. Francisco, Seung-Hyun Woo, Connor R. Criddle, Ardem Patapoutian, Dasha Zaytseva, Thomas M. Jessell |
المصدر: | Nature neuroscience |
بيانات النشر: | Springer Science and Business Media LLC, 2015. |
سنة النشر: | 2015 |
مصطلحات موضوعية: | Male, Sensory Receptor Cells, Mice, Transgenic, Sensory system, Biology, Mechanotransduction, Cellular, Article, Ion Channels, Mice, symbols.namesake, Ganglia, Spinal, medicine, Animals, Mechanotransduction, Cells, Cultured, Ion channel, Mice, Knockout, Movement Disorders, Proprioception, General Neuroscience, PIEZO1, Golgi apparatus, Tendon, medicine.anatomical_structure, symbols, Female, Neuroscience |
الوصف: | Proprioception, the perception of body and limb position, is mediated by proprioceptors, specialized mechanosensory neurons that convey information about the stretch and tension experienced by muscles, tendons, skin and joints. In mammals, the molecular identity of the stretch-sensitive channel that mediates proprioception is unknown. We found that the mechanically activated nonselective cation channel Piezo2 was expressed in sensory endings of proprioceptors innervating muscle spindles and Golgi tendon organs in mice. Two independent mouse lines that lack Piezo2 in proprioceptive neurons showed severely uncoordinated body movements and abnormal limb positions. Moreover, the mechanosensitivity of parvalbumin-expressing neurons that predominantly mark proprioceptors was dependent on Piezo2 expression in vitro, and the stretch-induced firing of proprioceptors in muscle-nerve recordings was markedly reduced in Piezo2-deficient mice. Together, our results indicate that Piezo2 is the major mechanotransducer of mammalian proprioceptors. |
تدمد: | 1546-1726 1097-6256 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847f622fa3dd10d2cd314b860b3a347f https://doi.org/10.1038/nn.4162 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....847f622fa3dd10d2cd314b860b3a347f |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15461726 10976256 |
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