SCFSlmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila
| العنوان: | SCFSlmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila |
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| المؤلفون: | Renjie Jiao, Changqing Li, Hanqing Chen, Hongtao Zhang, Wen Dui, Fei Dai, Chuanxian Wei, Honggang Wu, Wu-Min Deng |
| المصدر: | Cell Research. 25:93-109 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | endocrine system, animal structures, Protein Serine-Threonine Kinases, Bioinformatics, Cell Line, Ubiquitin, Transcription (biology), Animals, Drosophila Proteins, Protein Interaction Maps, Molecular Biology, Hippo signaling pathway, SKP Cullin F-Box Protein Ligases, biology, fungi, Intracellular Signaling Peptides and Proteins, Ubiquitination, Membrane Proteins, Cell Biology, Ubiquitin ligase, Cell biology, body regions, Hippo signaling, Cell culture, Proteolysis, biology.protein, Original Article, Drosophila, sense organs, Signal transduction, Protein Kinases, Homeostasis, Signal Transduction |
| الوصف: | Deregulation of the evolutionarily conserved Hippo pathway has been implicated in abnormal development of animals and in several types of cancer. One mechanism of Hippo pathway regulation is achieved by controlling the stability of its regulatory components. However, the executive E3 ligases that are involved in this process, and how the process is regulated, remain poorly defined. In this study, we identify, through a genetic candidate screen, the SCF(Slmb) E3 ligase as a novel negative regulator of the Hippo pathway in Drosophila imaginal tissues via mediation of the degradation of Expanded (Ex). Mechanistic study shows that Slmb-mediated degradation of Ex is inhibited by the Hippo signaling. Considering the fact that Hippo signaling suppresses the transcription of ex, we propose that the Hippo pathway employs a double security mechanism to ensure fine-tuned homeostasis during development. |
| تدمد: | 1748-7838 1001-0602 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848a380e3e4c8c20c6c3c90a42ca12f9 https://doi.org/10.1038/cr.2014.166 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....848a380e3e4c8c20c6c3c90a42ca12f9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17487838 10010602 |
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