The regulatory roles of motile cilia in CSF circulation and hydrocephalus
| العنوان: | The regulatory roles of motile cilia in CSF circulation and hydrocephalus |
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| المؤلفون: | Ravi Shankar Goutam, Zobia Umair, Soochul Park, Shiv Kumar, Jaebong Kim, Vijay Kumar |
| المساهمون: | University of St Andrews. School of Psychology and Neuroscience |
| المصدر: | Fluids and Barriers of the CNS Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-11 (2021) |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Ciliary motility, Ependymal Cell, T-NDAS, Review, Biology, Ciliopathies, Cerebral Ventricles, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Cerebrospinal fluid, Developmental Neuroscience, medicine, Animals, Humans, Cilia, RC346-429, Brain Ventricle, Cilium, Brain, Brain ventricular system, General Medicine, medicine.disease, Brain development, Hydrocephalus, 030104 developmental biology, medicine.anatomical_structure, Neurology, Ependymal cells, Motile cilium, RC0321, Cilipathies, Neurology. Diseases of the nervous system, Subarachnoid space, Neuroscience, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, 030217 neurology & neurosurgery |
| الوصف: | Background Cerebrospinal fluid (CSF) is an ultra-filtrated colorless brain fluid that circulates within brain spaces like the ventricular cavities, subarachnoid space, and the spine. Its continuous flow serves many primary functions, including nourishment, brain protection, and waste removal. Main body The abnormal accumulation of CSF in brain cavities triggers severe hydrocephalus. Accumulating evidence had indicated that synchronized beats of motile cilia (cilia from multiciliated cells or the ependymal lining in brain ventricles) provide forceful pressure to generate and restrain CSF flow and maintain overall CSF circulation within brain spaces. In humans, the disorders caused by defective primary and/or motile cilia are generally referred to as ciliopathies. The key role of CSF circulation in brain development and its functioning has not been fully elucidated. Conclusions In this review, we briefly discuss the underlying role of motile cilia in CSF circulation and hydrocephalus. We have reviewed cilia and ciliated cells in the brain and the existing evidence for the regulatory role of functional cilia in CSF circulation in the brain. We further discuss the findings obtained for defective cilia and their potential involvement in hydrocephalus. Furthermore, this review will reinforce the idea of motile cilia as master regulators of CSF movements, brain development, and neuronal diseases. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-8118 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849294a5cdeb194fba7181dbaf3d0ae5 http://europepmc.org/articles/PMC8261947 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....849294a5cdeb194fba7181dbaf3d0ae5 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20458118 |
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