Calibration and cross-validation of MCCB and CogState in schizophrenia
| العنوان: | Calibration and cross-validation of MCCB and CogState in schizophrenia |
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| المؤلفون: | Tracy Collier, Jane Lees, Panayiota G. Michalopoulou, Richard Emsley, Shôn Lewis, Eve Applegate, Richard Drake, Shitij Kapur, Cristina Lopez-Lopez, Gahan Pandina |
| المصدر: | BASE-Bielefeld Academic Search Engine |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Battery (electricity), alpha7 Nicotinic Acetylcholine Receptor, Alpha7 Nicotinic Acetylcholine Receptor, Modafinil, Schizoaffective disorder, Neuropsychological Tests, Cross-validation, Double-Blind Method, medicine, Humans, Attention, Nicotinic Agonists, Benzhydryl Compounds, Social Behavior, Cognitive impairment, Language, Pharmacology, Reproducibility of Results, Cognition, medicine.disease, Diagnostic and Statistical Manual of Mental Disorders, Psychotic Disorders, Schizophrenia, Calibration, Central Nervous System Stimulants, Female, Schizophrenic Psychology, Cognition Disorders, Psychology, Psychomotor Performance, medicine.drug, Clinical psychology |
| الوصف: | Cognitive impairment associated with schizophrenia is a key predictor of functional outcomes. The FDA-accepted MATRICS Consensus Cognitive Battery (MCCB) is held to be the gold standard measure but there are concerns about its ease of administration, reliance on language causing problems with translation and possible practice effects. The CogState Schizophrenia Battery (SB) is suggested as a non-language-based alternative but there is no substantial, independent comparison. The objective of this study was to assess the reliability and validity of these two assessment batteries. One hundred forty-three participants with DSM-IV schizophrenia and schizoaffective disorder were recruited into three similar studies. Each study administered MCCB and SB tests on consecutive days (baseline 1 and 2) and follow-up 3–4 weeks later. Batteries’ test-retest reliability was similar: SB composites correlated r = 0.66–0.78 between baselines, MCCB domains r = 0.69–0.90. Baseline 2 and follow-up SB composites correlated r = 0.65–0.80 and MCCB domains r = 0.62–0.87. MCCB tasks’ practice effects (Glass’ ∆ = 0.02–0.46) exceeded SB’s (Glass’ ∆ = 0.02–0.34). While the batteries’ total scores correlated strongly (r = 0.79–0.82), apparently equivalent cognitive domains on each battery (e.g. psychomotor-attention) correlated r = 0.22–0.60, indicating substantial differences between some supposed counterparts. Clinical trials using either battery would benefit from initial practice sessions to ameliorate practice effects but the SB may be more suitable to measure change in the absence of repeated baselines. The MCCB domains’ better correlations with social skills performance suggest that it may have an advantage for measuring cognition in relation to functional outcome. |
| تدمد: | 1432-2072 0033-3158 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84af0b2d0bce6bef30c364f3cb4a0b39 https://doi.org/10.1007/s00213-015-3960-8 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....84af0b2d0bce6bef30c364f3cb4a0b39 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14322072 00333158 |
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