Predictors of neonatal mortality: development and validation of prognostic models using prospective data from rural Bangladesh
| العنوان: | Predictors of neonatal mortality: development and validation of prognostic models using prospective data from rural Bangladesh |
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| المؤلفون: | Luke C. Mullany, Alain B. Labrique, Keith P. West, Lee F.S. Wu, Saijuddin Shaikh, Kelsey Alland, Hasmot Ali, Farhad A. Khan |
| المصدر: | BMJ Global Health BMJ Global Health, Vol 5, Iss 1 (2020) |
| بيانات النشر: | BMJ Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, neonatal mortality, Birth weight, 030231 tropical medicine, danger sign, Gestational Age, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Lethargy, Young Adult, 0302 clinical medicine, Neonatal Screening, Predictive Value of Tests, Pregnancy, Risk Factors, Childbirth, Medicine, prognostic model, Birth Weight, Humans, lcsh:RC109-216, 030212 general & internal medicine, newborn mortality, Perinatal Mortality, Original Research, Randomized Controlled Trials as Topic, lcsh:R5-920, Bangladesh, Models, Statistical, business.industry, Obstetrics, Neonatal mortality, Health Policy, Public Health, Environmental and Occupational Health, Infant, Newborn, Gestational age, Infant, medicine.disease, Prognosis, Verbal autopsy, symptom, Female, Presentation (obstetrics), lcsh:Medicine (General), business |
| الوصف: | ObjectiveTo assess the extent to which maternal histories of newborn danger signs independently or combined with birth weight and/or gestational age (GA) can capture and/or predict postsecond day (age>48 hours) neonatal death.MethodsData from a cluster-randomised trial conducted in rural Bangladesh were split into development and validation sets. The prompted recall of danger signs and birth weight measurements were collected within 48 hours postchildbirth. Maternally recalled danger signs included cyanosis (any part of the infant’s body was blue at birth), non-cephalic presentation (part other than head came out first at birth), lethargy (weak or no arm/leg movement and/or cry at birth), trouble suckling (infant unable to suckle/feed normally in the 2 days after birth or before death, collected 1-month postpartum or from verbal autopsy). Last menstrual period was collected at maternal enrolment early in pregnancy. Singleton newborns surviving 2 days past childbirth were eligible for analysis. Prognostic multivariable models were developed and internally validated.ResultsRecalling ≥1 sign of lethargy, cyanosis, non-cephalic presentation or trouble suckling identified postsecond day neonatal death with 65.3% sensitivity, 60.8% specificity, 2.1% positive predictive value (PPV) and 99.3% negative predictive value (NPV) in the development set. Requiring either lethargy or weight ConclusionMaternally recalled danger signs, coupled to either birth weight or GA, can predict and capture postsecond day neonatal death with high discrimination and sensitivity. |
| اللغة: | English |
| تدمد: | 2059-7908 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b3d4cd27c64466774af78a82788f9a http://europepmc.org/articles/PMC7042570 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....84b3d4cd27c64466774af78a82788f9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20597908 |
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