Tangeretin as an adjuvant and chemotherapeutic sensitizer against various types of cancers: a comparative overview
| العنوان: | Tangeretin as an adjuvant and chemotherapeutic sensitizer against various types of cancers: a comparative overview |
|---|---|
| المؤلفون: | Sara M. Elgendy, Hany A. Omar, Dima W. Alhamad, Taleb H. Al-Tel |
| المصدر: | Journal of Pharmacy and Pharmacology. 73:601-610 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmacology, 0303 health sciences, Cancer resistance, Cancer chemotherapy, business.industry, medicine.medical_treatment, Pharmaceutical Science, Cancer, Antineoplastic Agents, Flavones, medicine.disease, 03 medical and health sciences, Tangeretin, 0302 clinical medicine, Neoplasms, 030220 oncology & carcinogenesis, Antineoplastic Combined Chemotherapy Protocols, medicine, Cancer research, Humans, business, Adverse effect, Adjuvant, 030304 developmental biology |
| الوصف: | Objectives Cancer is a leading cause of disabling morbidities and death worldwide. Although there are various strategies for the management of cancer, the severe adverse effects negatively impact the patient’s quality of life. In addition, the development of resistance limits the efficacy of many chemotherapeutics. Many natural agents are capable of reducing the adverse effects associated with chemotherapy and improving the therapeutic outcome. Tangeretin, a polymethoxy flavone, is one of the promising natural anticancer agents. Key findings Tangeretin not only targets various malignancies but also synergizes chemotherapeutic agents and reverses cancer resistance. Hence, the application of tangeretin as an adjuvant in cancer chemotherapy would be a promising strategy. Summary This work critically highlighted the proposed anticancer activity of tangeretin and discussed its potential combination with various chemotherapeutic agents. Additionally, it shed light on tangeretin chemical derivatives with improved pharmacokinetic and pharmacodynamic activity. Finally, this review described flavonoid biosynthetic pathways and how bioengineering can be employed to enhance the production yield of tangeretin. Thus, this work paves the way for the rational clinical utilization of tangeretin as a safe and effective adjuvant in chemotherapeutic protocols. |
| تدمد: | 2042-7158 0022-3573 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e69817667f1f2a88a1b37d023a8b59 https://doi.org/10.1093/jpp/rgab013 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....84e69817667f1f2a88a1b37d023a8b59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20427158 00223573 |
|---|