Electroacupuncture preconditioning attenuates ischemic brain injury by activation of the adenosine monophosphate-activated protein kinase signaling pathway
| العنوان: | Electroacupuncture preconditioning attenuates ischemic brain injury by activation of the adenosine monophosphate-activated protein kinase signaling pathway |
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| المؤلفون: | Mingshan Wang, Fei Shi, Qiang-qiang Ran, Yan-li Liu, Hai-xia Yu, Huailong Chen |
| المصدر: | Neural Regeneration Research, Vol 10, Iss 7, Pp 1069-1075 (2015) Neural Regeneration Research |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adenosine monophosphate, Electroacupuncture, medicine.medical_treatment, Ischemia, neurons, Pharmacology, Neuroprotection, cerebral ischemia, lcsh:RC346-429, chemistry.chemical_compound, Developmental Neuroscience, electroacupuncture, medicine, nerve regeneration, NSFC grant, Protein kinase A, lcsh:Neurology. Diseases of the nervous system, compound C, adenosine monophosphate-activated protein kinase α, business.industry, apoptosis, AMPK, medicine.disease, Adenosine, chemistry, neuroprotection, neural regeneration, Signal transduction, business, Neuroscience, Research Article, medicine.drug |
| الوصف: | Electroacupuncture has therapeutic effects on ischemic brain injury, but its mechanism is still poorly understood. In this study, mice were stimulated by electroacupuncture at the Baihui (GV20) acupoint for 30 minutes at 1 mA and 2/15 Hz for 5 consecutive days. A cerebral ischemia model was established by ligating the bilateral common carotid artery for 15 minutes. At 72 hours after injury, neuronal injury in the mouse hippocampus had lessened, and the number of terminal deoxynucleotide transferase-mediated dUTP nick-end labeling-positive cells reduced after electroacupuncture treatment. Moreover, expression of adenosine monophosphate-activated protein kinase α (AMPKα) and phosphorylated AMPKα was up-regulated. Intraperitoneal injection of the AMPK antagonist, compound C, suppressed this phenomenon. Our findings suggest that electroacupuncture preconditioning alleviates ischemic brain injury via AMPK activation. |
| اللغة: | English |
| تدمد: | 1673-5374 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850591ed26ffcd5c62315ecbb9fc67bc http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=7;spage=1069;epage=1075;aulast=Ran |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....850591ed26ffcd5c62315ecbb9fc67bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16735374 |
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