Effect of Biospray Dressings on Eosinophil Infiltration in the Nasal Mucosa and Serum IgE Levels After Nasal Provocation in Experimental Allergic Rhinitis
| العنوان: | Effect of Biospray Dressings on Eosinophil Infiltration in the Nasal Mucosa and Serum IgE Levels After Nasal Provocation in Experimental Allergic Rhinitis |
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| المؤلفون: | Geping Wu, Shan Huang, Xingkai Ma, Ling Zhang, Hongyan Zhu, Yifang Yuan, Di Li, Xiaodan Gu, Yan Lv |
| المصدر: | Allergy & Rhinology Allergy & Rhinology, Vol 11 (2020) |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, Experimental allergic, Provocation test, Mucous membrane of nose, Immunoglobulin E, Serum ige, otorhinolaryngologic diseases, Immunology and Allergy, Medicine, Original Research, allergic rhinitis, biology, business.industry, Eosinophil, respiratory system, lcsh:Otorhinolaryngology, medicine.disease, lcsh:RF1-547, medicine.anatomical_structure, Otorhinolaryngology, serum IgE, biospray dressing, Immunology, biology.protein, eosinophils, lcsh:RC581-607, business, Infiltration (medical) |
| الوصف: | Purpose To investigate the effect of biospray dressing on the extent of eosinophil infiltration in the nasal mucosa and the level of serum IgE in experimental allergic rhinitis with nasal provocation. Method Twenty-four BALB/c mice were randomly divided into the normal control group, allergic rhinitis (AR) group, dexamethasone (DEX) treatment group, and biospray dressing (BD) group. The mice in the latter 3 groups were prepared for animal models of AR according to standard protocols. Mice in the BD group were administered a nasal spray before the nasal provocation, and those in the DEX group were administered an intraperitoneal injection of DEX. The nasal mucosa and serum were collected from each group. Nasal mucosa eosinophil infiltration was evaluated using hematoxylin and eosin staining, and enzyme-linked immunosorbent assay (ELISA) was performed to analyze the serum IgE expression. Results Eosinophil infiltration (AR vs BD P = .009) in the nasal mucosa and serum IgE expression (AR vs BD P = .001) were significantly lower in the BD group than in the AR group. There were no significant differences in the extent of eosinophil infiltration in the nasal mucosa or serum IgE expression between the BD and DEX groups. Conclusion Biospray dressings can significantly reduce allergen provocation in the nasal cavity and have a protective effect on the nasal mucosa. They can be used for the prevention and treatment of AR. |
| اللغة: | English |
| تدمد: | 2152-6567 2152-6575 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c6018a7e62b72b0656e2851814389a http://europepmc.org/articles/PMC7066584 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....85c6018a7e62b72b0656e2851814389a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21526567 21526575 |
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