WHOLE-CARCASS RESIDUES OF THE RODENTICIDE DIFENACOUM IN ANTICOAGULANT-RESISTANT AND -SUSCEPTIBLE RAT STRAINS (RATTUS NORVEGICUS)
| العنوان: | WHOLE-CARCASS RESIDUES OF THE RODENTICIDE DIFENACOUM IN ANTICOAGULANT-RESISTANT AND -SUSCEPTIBLE RAT STRAINS (RATTUS NORVEGICUS) |
|---|---|
| المؤلفون: | Gerard M. Kerins, Alan D. MacNicoll, Helen Atterby |
| المصدر: | Environmental Toxicology and Chemistry. 24:318 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Time Factors, Difenacoum, Health, Toxicology and Mutagenesis, Drug Resistance, Biology, Risk Assessment, Toxicology, chemistry.chemical_compound, Residue (chemistry), Animal science, Secondary poisoning, Animals, Environmental Chemistry, Ecotoxicology, Rodenticide, Chromatography, High Pressure Liquid, Body Weight, Pesticide Residues, Anticoagulants, Rodenticides, 4-Hydroxycoumarins, Pesticide, Animal Feed, Rats, Laboratory rat, chemistry, Toxicity, Blood Coagulation Tests |
| الوصف: | The present study investigated the whole-carcass residue carried by resistant and susceptible laboratory rat strains following 5, 10, or 20 d of feeding on a diet of 25 mg difenacoum/kg bait. The mean whole-carcass residue of difenacoum was determined by high-performance liquid chromatography to be between 0.52 and 0.74 mg/kg body weight in all three rat strains tested. These values were considerably lower than some comparable data previously reported for other species and second-generation rodenticides as well as from mathematical models. The whole-carcass residue of extractable (i.e., nonrefractory) parent compound carried by highly resistant rats fed for 20 d (0.74 mg/kg body wt) is unlikely to present a significantly increased risk to predators compared to the amount carried by susceptible rats after 5 d of feeding (0.52 mg/kg body wt). However, resistant rats are more likely to be available for predation and to be carrying a whole-carcass residue of anticoagulant throughout the duration of a control program. |
| تدمد: | 1552-8618 0730-7268 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dc165afe5f94b9aeeed9ba965ea796 https://doi.org/10.1897/04-022r.1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....85dc165afe5f94b9aeeed9ba965ea796 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15528618 07307268 |
|---|