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A cross-sectional comparison of epidemiological and clinical features of patients with coronavirus disease (COVID-19) in Wuhan and outside Wuhan, China

التفاصيل البيبلوغرافية
العنوان: A cross-sectional comparison of epidemiological and clinical features of patients with coronavirus disease (COVID-19) in Wuhan and outside Wuhan, China
المؤلفون: Wenxiong Xu, Zhiliang Gao, Xuejun Li, Hong Cao, Dabiao Chen, Jing Liu, Ziying Lei, Zhan-Lian Huang, Junfeng Chen, Yusheng Jie, Jianyun Zhu, Xiaoyan Guo, Xiao-Ling Dai, Huijuan Cao, Jian Rong He, Bing Liang Lin, Liang Peng
المصدر: Travel Medicine and Infectious Disease
بيانات النشر: Elsevier BV, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Male, CT, computerized tomography, Epidemiology, Cross-sectional study, Feces, 0302 clinical medicine, Pandemic, 030212 general & internal medicine, COVID-19, coronavirus disease 2019, Aged, 80 and over, Coronavirus disease 2019, Virulence, Transmission (medicine), Medical record, Mortality rate, Middle Aged, ICU, intensive care unit, PCT, Procalcitonin, Anti-Bacterial Agents, Hospitalization, Intensive Care Units, Diarrhea, Treatment Outcome, Infectious Diseases, RNA, Viral, Female, medicine.symptom, Coronavirus Infections, Adult, China, medicine.medical_specialty, Pneumonia, Viral, 030231 tropical medicine, CRP, C-reaction protein, Real-Time Polymerase Chain Reaction, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Antiviral Agents, Article, Betacoronavirus, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Transmission, Humans, CDC, Centre for Disease Control and Prevention, Pandemics, Aged, ESR, erythrocyte sedimentation rate, SARS-CoV-2, business.industry, Public Health, Environmental and Occupational Health, COVID-19, Clinical features, COVID-19 Drug Treatment, Cross-Sectional Studies, Severe acute respiratory syndrome-related coronavirus 2, RNA, ribonucleic acid, business, Follow-Up Studies
الوصف: Background Coronavirus disease 2019 (COVID-19) has spread outside the initial epicenter of Wuhan. We compared cases in Guangzhou and Wuhan to illustrate potential changes in pathogenicity and epidemiological characteristics as the epidemic has progressed. Methods We studied 20 patients admitted to the Third Affiliated Hospital of Sun Yat-Sen University in Guangzhou, China from January 22 to February 12, 2020. Data were extracted from medical records. These cases were compared with the 99 cases, previously published in Lancet, from Wuhan Jinyintan Hospital from January 1 to January 20, 2020. Results Guangzhou patients were younger and had better prognosis than Wuhan patients. The Wuhan patients were more likely to be admitted to the ICU (23% vs 5%) and had a higher mortality rate (11% vs 0%). Cases in Guangzhou tended to be more community clustered. Diarrhea and vomiting were more common among Guangzhou patients and SARS-CoV-2 RNA was found in feces. Fecal SARA-CoV-2 RNA remained positive when nasopharyngeal swabs turned negative in some patients. Conclusions This study indicates possible diminishing virulence of the virus in the process of transmission. Yet persistent positive RNA in feces after negative nasopharyngeal swabs suggests a possible prolonged transmission period that challenges current quarantine practices.
تدمد: 1477-8939
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dc36f91ec2fc67ec6e1b060758fccb
https://doi.org/10.1016/j.tmaid.2020.101664
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....85dc36f91ec2fc67ec6e1b060758fccb
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14778939