Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases
| العنوان: | Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases |
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| المؤلفون: | Salomé S. Pinho, Xavier Verhelst, Hans Van Vlierberghe, Severine Vermeire, Jean-Frederic Colombel, Nico Callewaert, Ana M. Dias |
| المصدر: | GASTROENTEROLOGY |
| بيانات النشر: | W B SAUNDERS CO-ELSEVIER INC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, MUCOSA-ASSOCIATED MICROBIOTA, Proteomics, Time Factors, Glycosylation, Gastrointestinal Diseases, T-Lymphocytes, N-ACETYLGLUCOSAMINYLTRANSFERASE-III, Malignant transformation, chemistry.chemical_compound, Liver disease, 0302 clinical medicine, HEPATOCELLULAR-CARCINOMA, Nonalcoholic fatty liver disease, Medicine and Health Sciences, Glycomics, GLYCAN INTERACTIONS, biology, NONALCOHOLIC STEATOHEPATITIS, Liver Diseases, Liver Disease, Gastroenterology, Prognosis, Glycan, CROHNS-DISEASE, Liver, Glycomic, 030211 gastroenterology & hepatology, Antibody, CHRONIC HEPATITIS-C, EARLY, IBD, 03 medical and health sciences, Immune system, Polysaccharides, medicine, Humans, BOWEL-DISEASE, Glycome, Hepatology, Biology and Life Sciences, medicine.disease, Gastrointestinal Tract, carbohydrates (lipids), 030104 developmental biology, chemistry, biology.protein, Cancer research, IMMUNOGLOBULIN-G, FUCOSYLATED GLYCOPROTEINS, Biomarkers |
| الوصف: | Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions. For example, specific glycans regulate T-cell activation, structures, and functions of immunoglobulins; interactions between microbes and immune and epithelial cells; and malignant transformation in the intestine and liver. We review the effects of protein glycosylation in regulation of gastrointestinal and liver functions, and how alterations in glycosylation serve as diagnostic or prognostic factors, or as targets for therapy. ispartof: GASTROENTEROLOGY vol:158 issue:1 pages:95-110 ispartof: location:United States status: published |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| تدمد: | 0016-5085 1528-0012 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ef1e2c34724da876eec074b191cc9c https://lirias.kuleuven.be/handle/123456789/645627 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....85ef1e2c34724da876eec074b191cc9c |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 00165085 15280012 |
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