Clinical outcome of posterior fixation surgery in patients with vertebral metastasis of lung cancer
| العنوان: | Clinical outcome of posterior fixation surgery in patients with vertebral metastasis of lung cancer |
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| المؤلفون: | Shoji Kitamura, Tetsuo Hori, Koji Teramoto, Jun Hanaoka, Masayuki Hashimoto, Keiko Ueda, Yo Kawaguchi, Keiko Ishida, Ryosuke Kaku, Tomoyuki Igarashi, Noriaki Tezuka, Keigo Okamoto |
| المصدر: | Molecular and Clinical Oncology. 6:770-774 |
| بيانات النشر: | Spandidos Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Activities of daily living, Performance status, business.industry, Cancer, Articles, medicine.disease, Surgery, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, medicine, Paralysis, 030212 general & internal medicine, medicine.symptom, Lung cancer, business, Contraindication, Chemoradiotherapy, Fixation (histology) |
| الوصف: | Vertebral metastasis of non-small-cell lung cancer (NSCLC) often leads to neurological paralysis, with deterioration of the patients' activities of daily living (ADL). Surgical treatments for the symptoms are unlikely to be recommended due to the poor prognosis of patients with advanced NSCLC. The aim of the present study was to retrospectively evaluate the clinical outcome of posterior spinal fixation surgery in patients with neurological paralysis resulting from vertebral metastasis of NSCLC. Between April, 2007 and March, 2012, 4 patients (3 men and 1 woman; median age, 56.5 years) underwent fixation surgery at the Shiga University of Medical Science Hospital (Otsu, Japan). The mean preoperative Tokuhashi and Tomita scores of the patients were high (8.25 and 7.0, respectively). However, the Frankel grade functional score and performance status of the patients improved following fixation surgery, after which all patients received chemoradiotherapy. Postoperatively, the median paralysis-free time was 41 months (range, 17-42 months) and the median survival time was 42.5 months (range, 22-43 months). According to the functional scores, the patients had a poor prognosis, which may have been a contraindication for fixation surgery. In these cases, however, surgical treatment improved the patients' ADL and increased the likelihood of receiving anticancer therapy, contributing to the prolongation of survival. Therefore, fixation surgery may be beneficial for patients with neurological paralysis following vertebral metastasis of advanced NSCLC. |
| تدمد: | 2049-9469 2049-9450 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fcade27491269f0966e2102de7a15b https://doi.org/10.3892/mco.2017.1199 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....85fcade27491269f0966e2102de7a15b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20499469 20499450 |
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