Pulmonary infections following immunosuppressive treatments during hospitalization worsen the short-term vital prognosis for patients with connective tissue disease-associated interstitial pneumonia
| العنوان: | Pulmonary infections following immunosuppressive treatments during hospitalization worsen the short-term vital prognosis for patients with connective tissue disease-associated interstitial pneumonia |
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| المؤلفون: | Yasunari Miyazaki, Hayato Yamazaki, Yasushi Kawaguchi, Yasuhiko Nishioka, Kazuyoshi Saito, Makoto Dohi, Ryoko Sakai, Hideto Kameda, Masako Hara, Kaori Watanabe, Yuko Kaneko, Ryuji Koike, Masayoshi Harigai, Nobuyuki Miyasaka, Hayato Nagasawa, Shigeto Tohma, Yoshinari Takasaki, Toshihiro Nanki, Shintaro Hirata, Shinsuke Yasuda, Michi Tanaka |
| المصدر: | Modern Rheumatology. 25:609-614 |
| بيانات النشر: | Oxford University Press (OUP), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, genetic processes, Connective tissue, Risk Assessment, environment and public health, Polymyositis, Mixed connective tissue disease, Japan, Rheumatology, Risk Factors, Internal medicine, medicine, Humans, Hospital Mortality, Connective Tissue Diseases, Respiratory Tract Infections, Aged, Retrospective Studies, business.industry, fungi, Overlap syndrome, Middle Aged, Dermatomyositis, Prognosis, medicine.disease, Connective tissue disease, Surgery, Hospitalization, Survival Rate, enzymes and coenzymes (carbohydrates), medicine.anatomical_structure, Rheumatoid arthritis, health occupations, Female, Lung Diseases, Interstitial, business, Microscopic polyangiitis, Immunosuppressive Agents, Follow-Up Studies |
| الوصف: | Connective tissue disease-associated interstitial pneumonia (CTD-IP) significantly affects the mortality of patients with CTD. The purpose of the present study is to identify causes and risk factors for death during hospitalization for immunosuppressive treatment of CTD-IP.A multicenter, retrospective study was conducted that collected data from patients with CTD who had been hospitalized for commencing or intensifying immunosuppressive treatment of CTD-IP using a standardized case report form. Risk factors were identified using the Cox proportional hazard regression model.A total of 322 CTD-IP patients were enrolled with rheumatoid arthritis (n = 84), systemic lupus erythematosus (n = 13), polymyositis (n = 33), dermatomyositis (n = 69), systemic sclerosis (n = 55), mixed connective tissue disease (n = 21), microscopic polyangiitis (n = 19), and overlap syndrome (n = 28). Of the 42 patients who died during hospitalization, 22 died from CTD-IP, 15 from CTD-IP and pulmonary infection, 2 from pulmonary infection, and 3 from other causes. Age ≥ 65 years and development of pulmonary infections after commencing or intensifying immunosuppressive treatments were identified as risk factors for death during hospitalization after adjusting for covariates.Careful consideration of the benefit-risk balance of immunosuppressive treatment for CTD-IP is indispensable for improving the short-term vital prognosis of these patients. |
| تدمد: | 1439-7609 1439-7595 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8621ecf638cf4387eef895570f76277c https://doi.org/10.3109/14397595.2014.980384 |
| رقم الأكسشن: | edsair.doi.dedup.....8621ecf638cf4387eef895570f76277c |
| قاعدة البيانات: | OpenAIRE |
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