Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis
| العنوان: | Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis |
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| المؤلفون: | Qingfa Wu, Guang Zhang, Yide Mei, Yang Yang, Zhongyu Wang, Bingyan Li, Yu Zhu, Kaiyue Liu, Hao Hu |
| المصدر: | Oncogene. 40:2936-2951 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Carcinoma, Hepatocellular, Carcinogenesis, Biology, Transfection, medicine.disease_cause, Serine, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, Humans, Phosphoglycerate dehydrogenase, Molecular Biology, Transcription factor, Competing endogenous RNA, Liver Neoplasms, ATF4, Cancer, medicine.disease, Cell biology, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, RNA, Long Noncoding |
| الوصف: | Cancer cells undergo metabolic adaption to sustain their survival and growth under metabolic stress conditions, yet the underlying mechanism remains largely unclear. It is also not known if lncRNAs contribute to this metabolic adaption of cancer cells. Here we show that linc01564 is induced in response to glucose deprivation by the transcription factor ATF4. Linc01564 functions to facilitate hepatocellular carcinoma cell survival under glucose deprivation by activating the serine synthesis pathway. Mechanistically, linc01564 acts as a competing endogenous RNA for miR-107/103a-3p and attenuates the inhibitory effect of miR-107/103a-3p on PHGDH, the rate-limiting enzyme of the serine synthesis pathway, thereafter leading to increased PHGDH expression. Furthermore, linc01564 is able to promote hepatocellular carcinogenesis via PHGDH. Together, these findings suggest that linc01564 is an important player in the regulation of metabolic adaption of cancer cells and also implicate linc01564 as a potential therapeutic target for cancer. |
| تدمد: | 1476-5594 0950-9232 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86477c69a49083e64c59e28e4b92b14e https://doi.org/10.1038/s41388-021-01749-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....86477c69a49083e64c59e28e4b92b14e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765594 09509232 |
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