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Carolina Hungaro Cunha,1 Debora Yuri Sato,1 Jose Maria Pereira de Godoy,2 Gleison Juliano da Silva Russeff,1 Desirée Franccini Del Frari Silva,1 Henrique Jose Pereira de Godoy,3 Mariana Orate Menezes da Silva,4 Henrique Amorim Santos,4 Maria de Fatima Guerreiro Godoy5 1Ecography Service in Hospital de Base-FUNFARME/FAMERP, Sao Jose do Rio Preto, Brazil; 2Cardiology and Cardiovascular Surgery Department Sao Jose do Rio Preto School Medicine-FAMERP, Sao Jose do Rio Preto, Brazil; 3General Surgery Department São Jose do Rio Preto School Medicine-FAMERP, Sao Jose do Rio Preto, Brazil; 4Vascular Surgery Service São Jose do Rio Preto School Medicine-FAMERP, Sao Jose do Rio Preto, Brazil; 5Post-Graduate Program São José do Rio Preto-FAMERP, Sao Jose do Rio Preto School Medicine-FAMERP, Sao Jose do Rio Preto, BrazilCorrespondence: Jose Maria Pereira de Godoy, Cardiology and Cardiovascular Surgery Department São Jose do Rio Preto School Medicine-FAMERP, Rua Floriano Peixoto, São Jose do Rio Preto, SP, 2950, Brazil, Tel/Fax +551732326362, Email godoyjmp@gmail.comPurpose: The SARS-CoV-2 disease predisposes infected individuals to thrombosis, the underlying mechanisms of which are not fully understood. The balance between pro-coagulant factors and natural coagulation inhibitors in critically ill patients with Covid-19 is fundamental to the prevention and treatment of complications. The aim of the present study was to investigate the pulmonary injury patterns in Covid-19 having higher mortality in the presence of deep vein thrombosis in comparison to patients without venous thrombosis and determine the Gamma variant.Methods: A retrospective study was conducted involving the evaluation of 200 medical records of patients with Covid-19 and a clinical suspicion of deep vein thrombosis (DVT) at the intensive care unit of a public hospital. The sample was divided into two groups of patients were formed â those positive and those negative for DVT. Statistical analysis involved the use of Fisherâs exact test, the paired t-test and chi-square test.Results: Patients with DVT had more severe lung injuries (greater than 70%) compared to those without DVT (p = 0.003). Lesions affecting 50% to 70% of the lung area occurred in little more half of the group with DVT and just under half in the group without DVT (p = 0.5). Pulmonary lesions affecting less than 50% of the lung occurred more in patients without DVT (p = 0.0001). The Gamma variant increased prevalence of the both DVT and mortality (p=0.0001).Conclusion: Deep vein thrombosis is an aggravating factor of mortality in patients with SARS-CoV-2, and the Gamma variant is an aggravating factor of both thrombotic events and mortality.Keywords: Covid-19, deep vein thrombosis, pulmonary thrombosis, mortality |
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