Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart
| العنوان: | Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart |
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| المؤلفون: | Michalis Mastri, Ioanna-Katerina Aggeli, Catherine Gaitanaki, Isidoros Beis |
| المصدر: | Journal of Experimental Biology. 211:2524-2532 |
| بيانات النشر: | The Company of Biologists, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Acetonitriles, Time Factors, Proto-Oncogene Proteins c-jun, Physiology, p38 mitogen-activated protein kinases, Apoptosis, In Vitro Techniques, Aquatic Science, Guanidines, p38 Mitogen-Activated Protein Kinases, Superoxide dismutase, Electrocardiography, Hsp27, Heat shock protein, Animals, Benzothiazoles, Sulfones, Phosphorylation, Ouabain, Protein kinase A, Molecular Biology, Heat-Shock Proteins, Ecology, Evolution, Behavior and Systematics, Anthracenes, chemistry.chemical_classification, Reactive oxygen species, biology, Caspase 3, Superoxide Dismutase, Kinase, Myocardium, JNK Mitogen-Activated Protein Kinases, Hyperthermia, Induced, Catalase, Molecular biology, Perfusion, Biochemistry, chemistry, Insect Science, biology.protein, Animal Science and Zoology, Anura, Poly(ADP-ribose) Polymerases |
| الوصف: | SUMMARY In the present study the activation of p38 mitogen-activated protein kinase(p38-MAPK) and c-Jun N-terminal kinases (JNKs) by hyperthermia was investigated in the isolated perfused Rana ridibunda heart. Hyperthermia (42°C) was found to profoundly stimulate p38-MAPK phosphorylation within 0.5 h, with maximal values being attained at 1 h[4.503(±0.577)-fold relative to control, P |
| تدمد: | 1477-9145 0022-0949 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c1c56618f1df4b6046589432f03e4b https://doi.org/10.1242/jeb.018960 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....86c1c56618f1df4b6046589432f03e4b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779145 00220949 |
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