Risk factors for impaired pulmonary function and cardiorespiratory fitness in very long-term adult survivors of childhood acute lymphoblastic leukemia after treatment with chemotherapy only
| العنوان: | Risk factors for impaired pulmonary function and cardiorespiratory fitness in very long-term adult survivors of childhood acute lymphoblastic leukemia after treatment with chemotherapy only |
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| المؤلفون: | Elisabeth Edvardsen, Jon R Christensen, May Brit Lund, Liv Ingunn Bjoner Sikkeland, Ole Henrik Myrdal, Johny Kongerud, Ellen Ruud, Adriani Kanellopoulos |
| المصدر: | Acta Oncologica. 57:658-664 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Cross-sectional study, medicine.medical_treatment, MEDLINE, Antineoplastic Agents, 030204 cardiovascular system & hematology, Pulmonary function testing, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, hemic and lymphatic diseases, medicine, Humans, Anthracyclines, Radiology, Nuclear Medicine and imaging, Survivors, Young adult, Child, Cyclophosphamide, Childhood Acute Lymphoblastic Leukemia, Chemotherapy, business.industry, Infant, Cardiorespiratory fitness, Hematology, General Medicine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Respiratory Function Tests, Cross-Sectional Studies, Methotrexate, Cardiorespiratory Fitness, Oncology, Echocardiography, Vincristine, Child, Preschool, 030220 oncology & carcinogenesis, Exercise Test, Respiratory Physiological Phenomena, Female, business, After treatment |
| الوصف: | Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of late treatment-related side-effects. Data regarding prevalence and risk factors for impairments in pulmonary function and cardiorespiratory fitness are limited, and reported findings are inconsistent and inconclusive.In a cross-sectional study, 116 ALL survivors (median 5 years at diagnosis, 29 years at follow-up, 53% females) were examined, median 23 years after treatment with chemotherapy only. Individual cumulative doses of cytostatic agents were calculated. Methods included blood tests, echocardiography, pulmonary function tests and cardiorespiratory exercise test.Females had lower % predicted gas diffusing capacity (DLCO) than males (mean [SD] 84 [13] versus 97 [14], p .001). Impairment in DLCO was found in 34% females versus 7% males, p .001. In a multiple linear regression model, female gender, body mass index (BMI) and smoking were risk factors for reduced % predicted DLCO, with a borderline significant effect of left ventricular ejection fraction (LVEF). Impaired cardiorespiratory fitness was found in 42% of the survivors, with a borderline increased risk in females, p = .06. Smoking and BMI were risk factors for reduced % predicted VOImpairments in pulmonary function and cardiorespiratory fitness are common in very long-term survivors of childhood ALL. Risk factors are female gender, BMI and smoking. In order to preserve pulmonary function and cardiorespiratory fitness, we suggest increased attention and targeted advice on modifiable lifestyle factors such as smoking, inactivity and overweight. |
| تدمد: | 1651-226X 0284-186X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cde7e0def9d2253ccf4edba73276f2 https://doi.org/10.1080/0284186x.2017.1423177 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....86cde7e0def9d2253ccf4edba73276f2 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 1651226X 0284186X |
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