Hepatokines as a Molecular Transducer of Exercise
| العنوان: | Hepatokines as a Molecular Transducer of Exercise |
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| المؤلفون: | Jun Hyun Bae, Jubert Marquez, Tae Nyun Kim, Se Hwan Park, Hyo-Bum Kwak, Dae Yun Seo, Jin-Ho Koh, Jin Han |
| المصدر: | Journal of Clinical Medicine, Vol 10, Iss 385, p 385 (2021) Journal of Clinical Medicine |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | angiopoietin-like protein 4, FGF21, lcsh:Medicine, 030209 endocrinology & metabolism, Disease, Type 2 diabetes, Review, Bioinformatics, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, medicine, follistatin, Endocrine system, 030304 developmental biology, 0303 health sciences, hepatokines, biology, exercise, business.industry, Fatty liver, lcsh:R, General Medicine, medicine.disease, fetuin-A, biology.protein, Metabolic syndrome, business, Follistatin |
| الوصف: | Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), and cardiovascular disease (CVD). Besides this, the importance of the liver as an endocrine organ is a hot research topic. Hepatocytes also secrete many hepatokines in response to nutritional conditions and/or physical activity. In particular, certain hepatokines play a major role in the regulation of whole-body metabolic homeostasis. In this review, we summarize the recent research findings on the exercise-mediated regulation of hepatokines, including fibroblast growth factor 21, fetuin-A, angiopoietin-like protein 4, and follistatin. These hepatokines serve as molecular transducers of the metabolic benefits of physical activity in chronic metabolic diseases, including NAFLD, T2D, and CVDs, in various tissues. |
| اللغة: | English |
| تدمد: | 2077-0383 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8707f127509c940a8cf70af53be1d4df https://www.mdpi.com/2077-0383/10/3/385 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8707f127509c940a8cf70af53be1d4df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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