An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress
| العنوان: | An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress |
|---|---|
| المؤلفون: | Sajita Shah-Morales, Yi Zuo, Ju Lu, Brian R. Mullen, Kacper Lukasiewicz, Lu Chen, Lindsay P. Cameron, Sydney Weiser, David E. Olson, Michelle Tjia, Bing Cao |
| المصدر: | Molecular psychiatry, vol 26, iss 11 Molecular Psychiatry |
| بيانات النشر: | eScholarship, University of California, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Dendritic spine, Sensory processing, medicine.medical_treatment, 1.1 Normal biological development and functioning, Sensory system, Biology, Somatosensory system, Basic Behavioral and Social Science, Medical and Health Sciences, Article, Cellular and Molecular Neuroscience, Mice, Calcium imaging, Underpinning research, Behavioral and Social Science, Biological neural network, medicine, Premovement neuronal activity, Animals, 2.1 Biological and endogenous factors, Aetiology, Molecular Biology, Neurons, Psychiatry, Psychology and Cognitive Sciences, Cognitive flexibility, Neurosciences, Somatosensory Cortex, Biological Sciences, Brain Disorders, Psychiatry and Mental health, Mental Health, Vibrissae, Neurological, Hallucinogens, Psychiatric disorders, Neuroscience |
| الوصف: | Psychological stress affects a wide spectrum of brain functions and poses risks for many mental disorders. However, effective therapeutics to alleviate or revert its deleterious effects are lacking. A recently synthesized psychedelic analog tabernanthalog (TBG) has demonstrated anti-addictive and antidepressant potential. Whether TBG can rescue stress-induced affective, sensory, and cognitive deficits, and how it may achieve such effects by modulating neural circuits, remain unknown. Here we show that in mice exposed to unpredictable mild stress (UMS), administration of a single dose of TBG decreases their anxiety level and rescues deficits in sensory processing as well as in cognitive flexibility. Post-stress TBG treatment promotes the regrowth of excitatory neuron dendritic spines lost during UMS, decreases the baseline neuronal activity, and enhances whisking-modulation of neuronal activity in the somatosensory cortex. Moreover, calcium imaging in head-fixed mice performing a whisker-dependent texture discrimination task shows that novel textures elicit responses from a greater proportion of neurons in the somatosensory cortex than do familiar textures. Such differential response is diminished by UMS and is restored by TBG. Together, our study reveals the effects of UMS on cortical neuronal circuit activity patterns and demonstrate that TBG combats the detrimental effects of stress by modulating basal and stimulus-dependent neural activity in cortical networks. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8712097106bec1f62c142db763923fa7 https://escholarship.org/uc/item/9d81b3xq |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8712097106bec1f62c142db763923fa7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |