The combined use of miRNAs and mRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma
| العنوان: | The combined use of miRNAs and mRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma |
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| المؤلفون: | Lili Zhong, Yinlong Zhao, Mengzi He, Shumei Ma, Silin Chen, Tiejun Wang, Xiaodong Liu |
| المصدر: | International Journal of Molecular Medicine. 36:1097-1103 |
| بيانات النشر: | Spandidos Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Thyroid carcinoma, Biomarkers, Tumor, Genetics, medicine, Humans, PTEN, RNA, Messenger, RNA, Neoplasm, Thyroid Neoplasms, Thyroid cancer, biology, Oncogene, Carcinoma, Thyroid, Cancer, General Medicine, medicine.disease, Carcinoma, Papillary, Neoplasm Proteins, MicroRNAs, medicine.anatomical_structure, Thyroid Cancer, Papillary, Tumor progression, biology.protein, Biomarker (medicine), Female |
| الوصف: | Thyroid carcinoma (TC) is the most common malignancy of the endocrine system, and papillary thyroid carcinoma (PTC) accounts for the largest proportion of cases with TC. Although histology is considered the gold standard in the diagnosis of PTC, the sensitivity and specificity of this method is low. Therefore, developing novel diagnostic and prognostic biomarkers for PTC is essential. MicroRNAs (miRNAs or miRs) and their target RNAs play critical roles in tumorigenesis and tumor progression. Thus, the characteristic miRNA and mRNA expression profiles may function as diagnostic biomarkers for tumors, making it possible to predict the tumor stage and the prognosis of patients. In the present study, we detected miRNAs and mRNAs which can function as novel biomarkers for the diagnosis of PTC. The sensitivity of the diagnostic tests was evaluated by receiver operating characteristic curve analysis. Pearson's correlation analysis was used to determine the correlation between mRNAs and miRNAs, and cancer types. We found that the area under the curve (AUC) values of 8 miRNAs (miR-106a, miR-15a, miR-30a, miR-30b, miR-20a, miR-20b, miR-30d and miR-30e) and 8 mRNAs [axis inhibition protein 2 (AXIN2), integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), tumor protein p53 inducible nuclear protein (TP53INP)1, TP53INP2, B-cell CLL/lymphoma 2 (BCL2), phosphatase and tensin homolog (PTEN), FOS and K(lysine) acetyltransferase 2B (KAT2B)] were >0.90. The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy. Therefore, our data indicate that the differential expression of miRNAs combined with that of their target mRNAs may serve as a powerful biomarker for distinguishing PTC from benign tissues. |
| تدمد: | 1791-244X 1107-3756 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871565b6b0deb16b657f9e0003cc42e6 https://doi.org/10.3892/ijmm.2015.2305 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....871565b6b0deb16b657f9e0003cc42e6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1791244X 11073756 |
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