التفاصيل البيبلوغرافية
| العنوان: |
Long-term Excretion of Gadolinium-based Contrast Agents: Linear versus Macrocyclic Agents in an Experimental Rat Model |
| المؤلفون: |
Jessica Lohrke, Gregor Jost, Volker Nischwitz, Thomas Frenzel, Janina Boyken, Hubertus Pietsch |
| المصدر: |
Radiology. 290(2) |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
Gadolinium DTPA, Male, medicine.medical_treatment, Gadolinium, chemistry.chemical_element, Contrast Media, Deep cerebellar nuclei, Mass Spectrometry, Gadobutrol, Excretion, medicine, Animals, Radiology, Nuclear Medicine and imaging, Saline, Brain Chemistry, Gadoteridol, medicine.diagnostic_test, business.industry, Gadodiamide, Brain, Magnetic resonance imaging, Magnetic Resonance Imaging, Rats, chemistry, Cerebellar Nuclei, Nuclear medicine, business, medicine.drug, Brain Stem |
| الوصف: |
Purpose To investigate the long-term course of MRI signal intensity (SI) changes and the presence of gadolinium in the rat brain during a 1-year period after multiple administrations of gadolinium-based contrast agents (GBCAs). Materials and Methods Rats received a linear GBCA (gadodiamide, gadopentetate dimeglumine, gadobenate dimeglumine), a macrocyclic GBCA (gadobutrol, gadoterate meglumine, gadoteridol), or saline. Animals received eight injections over 2 weeks (1.8 mmol/kg per injection). Brain MRI and gadolinium measurements were performed with inductively coupled plasma mass spectrometry (ICP-MS) and laser ablation ICP-MS 5, 26, and 52 weeks after administration. Results Animals that received linear GBCAs showed higher deep cerebellar nuclei (DCN)-to-brainstem SI ratios compared with the saline group (P.001 at all time points). After 1 year, mean gadolinium concentrations in the cerebellum were 3.38 nmol/g (gadodiamide), 2.13 nmol/g (gadopentetate dimeglumine), and 1.91 nmol/g (gadobenate dimeglumine). For linear agents, laser ablation ICP-MS revealed gadolinium depositions in the cerebellar nuclei. For macrocyclic GBCAs, the DCN-to-brainstem SI ratios did not significantly differ from those in the saline group (P.42) and the cerebellar gadolinium concentrations decreased between weeks 5 and 52, reaching 0.08 nmol/g (gadobutrol), 0.04 nmol/g (gadoterate meglumine), and 0.07 nmol/g (gadoteridol). The respective laser ablation ICP-MS analysis showed no gadolinium depositions. Conclusion Increased signal intensity in the deep cerebellar nuclei of rats persists for at least 1 year after administration of linear gadolinium-based contrast agents (GBCAs), in line with persistent brain gadolinium concentrations with no elimination after the initial 5-week period. The animals that received macrocyclic GBCAs showed an ongoing elimination of gadolinium from the brain during the entire observation period. © RSNA, 2018. |
| تدمد: |
1527-1315 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8726089d699569a2b83255ee9e1ea596
https://pubmed.ncbi.nlm.nih.gov/30806598 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....8726089d699569a2b83255ee9e1ea596 |
| قاعدة البيانات: |
OpenAIRE |
