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Haplotypes of the bovine IgG2 heavy gamma chain in tick-resistant and tick-susceptible breeds of cattle

التفاصيل البيبلوغرافية
العنوان: Haplotypes of the bovine IgG2 heavy gamma chain in tick-resistant and tick-susceptible breeds of cattle
المؤلفون: José Otavio F. Paula, Sandra Regina Maruyama, F. G. C. Arnoldi, Antônio Augusto Mendes Maia, Alexandre Rodrigues Caetano, P. Ianella, Marcia R.M. Silva, Isabel Kinney Ferreira de Miranda Santos, W. A. Carvalho, Beatriz Rossetti Ferreira, Luís Henrique Andreucci Conti
المصدر: Immunogenetics
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
سنة النشر: 2010
مصطلحات موضوعية: Male, Rhipicephalus (Boophilus) microplus, Immunoglobulin gamma-Chains, Immunology, Molecular Sequence Data, Cattle Diseases, Single-nucleotide polymorphism, CARRAPATOS, Tick, Brief Communication, Polymorphism, Single Nucleotide, Salivary Glands, Ticks, Genotype, parasitic diseases, Genetics, Animals, Genetic Predisposition to Disease, Amino Acid Sequence, Bovine IgG2, Hinge region, biology, Base Sequence, Haplotype, biology.organism_classification, Breed, Tick Infestations, Rhipicephalus, Haplotypes, Immunoglobulin heavy chain, Cattle, Allotypes, Immunoglobulin Heavy Chains
الوصف: Bovines present contrasting, heritable phenotypes of infestations with the cattle tick, Rhipicephalus (Boophilus) microplus. Tick salivary glands produce IgG-binding proteins (IGBPs) as a mechanism for escaping from host antibodies that these ectoparasites ingest during blood meals. Allotypes that occur in the constant region of IgG may differ in their capacity to bind with tick IGBPs; this may be reflected by the distribution of distinct allotypes according to phenotypes of tick infestations. In order to test this hypothesis, we investigated the frequency of haplotypes of bovine IgG2 among tick-resistant and tick-susceptible breeds of bovines. Sequencing of the gene coding for the heavy chain of IgG2 from 114 tick-resistant (Bos taurus indicus, Nelore breed) and tick-susceptible (B. t. taurus, Holstein breed) bovines revealed SNPs that generated 13 different haplotypes, of which 11 were novel and 5 were exclusive of Holstein and 3 of Nelore breeds. Alignment and modeling of coded haplotypes for hinge regions of the bovine IgG2 showed that they differ in the distribution of polar and hydrophobic amino acids and in shape according to the distribution of these amino acids. We also found that there was an association between genotypes of the constant region of the IgG2 heavy chain with phenotypes of tick infestations. These findings open the possibility of investigating if certain IgG allotypes hinder the function of tick IGBPs. If so, they may be markers for breeding for resistance against tick infestations. Electronic supplementary material The online version of this article (doi:10.1007/s00251-011-0515-y) contains supplementary material, which is available to authorized users.
تدمد: 1432-1211
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873f234aec1b6260d4b032495ffbf65c
https://pubmed.ncbi.nlm.nih.gov/21301827
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....873f234aec1b6260d4b032495ffbf65c
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14321211