Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra

التفاصيل البيبلوغرافية
العنوان: Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra
المؤلفون: Bora Nam, Okjin Kim, Hyun-A Lee, Jisoo Kim, Jooyun Kim
المصدر: Laboratory Animal Research, Vol 36, Iss 1, Pp 1-8 (2020)
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, Lactobacillus paracasei, Perilla frutescens var. acuta, Glycyrrhiza glabr, Virulence, Drug resistance, Microbiology, 03 medical and health sciences, 0302 clinical medicine, medicine, CagA, lcsh:QH301-705.5, lcsh:R5-920, HP7, Perilla frutescens, Helicobacter pylori, biology, Stomach, food and beverages, biology.organism_classification, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), 030220 oncology & carcinogenesis, Glycyrrhiza, lcsh:Medicine (General)
الوصف: The effect of standard therapeutic strategies on Helicobacter pylori infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm the enhanced effect of L. paracasei HP7, which has been reported to exert antibacterial and gastric mucosal protective effects, in combination with Perilla frutescens var. acuta (P. frutescens)and Glycyrrhiza glabra (G. glabra) extracts. P. frutescens extract and G. glabra extract were found to inhibit the growth of H. pylori in a concentration-dependent manner, and the combination of L. paracasei HP7 and P. frutescens extract and G. glabra extract effectively inhibited H. pylori from attaching to AGS a gastric epithelial cells. Moreover, L. paracasei HP7 complex mixture containing P. frutescens and G. glabra extracts has been shown to inhibit H. pylori virulence genes such as AlpA, CagA, FlaA and UreA. When H. pylori-infected mice were administered a complex mixture of L. paracasei HP7 containing P. frutescens and G. glabra extract, the infection rate of H. pylori was significantly reduced. In addition, the L. paracasei HP7 complex mixture significantly reduced serum IL-8 levels and stomach inflammation in H. pylori infected mice. These results suggest that a complex mixture of L. paracasei HP7 containing P. frutescens and G. glabra extracts may be an alternative to treating diseases caused by H. pylori infection.
تدمد: 2233-7660
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875d5f23bffb61838a052263090e269c
https://doi.org/10.1186/s42826-020-00073-x
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....875d5f23bffb61838a052263090e269c
قاعدة البيانات: OpenAIRE