Hybrid capture II for high-risk human papillomavirus DNA testing to detect cervical precancerous lesions: A qualitative and quantitative study
| العنوان: | Hybrid capture II for high-risk human papillomavirus DNA testing to detect cervical precancerous lesions: A qualitative and quantitative study |
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| المؤلفون: | Min Hao, Jiao-Ying Cheng, Mei-lu Bian, Wei Xiao, Jun Liu, Li Ma, Ying Chen, Juan Zhu |
| المصدر: | Experimental and Therapeutic Medicine. 1:193-198 |
| بيانات النشر: | Spandidos Publications, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Colposcopy, Cervical cancer, Cancer Research, medicine.medical_specialty, Pathology, medicine.diagnostic_test, business.industry, virus diseases, Cancer, Articles, General Medicine, medicine.disease, Cervical intraepithelial neoplasia, Gastroenterology, female genital diseases and pregnancy complications, Immunology and Microbiology (miscellaneous), Internal medicine, Cytology, medicine, Histopathology, Clinical significance, business, Viral load |
| الوصف: | Hybrid capture II (HC-II) is the only technique that can be used in clinical human papillomavirus (HPV) DNA detection. However, there is controversy in regards to how to analyze and assess the viral load of high-risk (HR)-HPV by use of HC-II and the relation between viral load and cervical lesions. In this study, we analyzed the results of a sequential screening of outpatients at the Department of Obstetrics and Gynecology of the China-Japan Friendship Hospital, and we aimed to explore the relationship between HR-HPV viral load and the severity of cervical lesions, and to clarify the clinical significance of the titer of HR-HPV DNA determined by HC-II. Using HC-II, 2,761 women were screened for HR-HPV DNA combined with cytological testing using liquid-based cytology. All women with HR-HPV-positive results or abnormalities in cytology underwent a cervical biopsy through colposcopy. Cervical biopsies were taken in 1,051 women. The HR-HPV infection rate was 78.35% (76/97) in HPV-associated lesions, 87.33% (193/221) in cervical intraepithelial neoplasia (CIN) I, 94.74% (144/152) in CIN II, 100% (178/178) in CIN III and 100% (20/20) in invasive cervical cancer (ICC), respectively (P |
| تدمد: | 1792-1015 1792-0981 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87de2773674e6db3710d904180cf2ba8 https://doi.org/10.3892/etm_00000031 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....87de2773674e6db3710d904180cf2ba8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921015 17920981 |
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