Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses
| العنوان: | Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses |
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| المؤلفون: | George A. Pitoc, Elizabeth Ramsburg, Kara L. Shumansky, Bruce A. Sullenger, Eda K. Holl |
| المصدر: | PLoS ONE, Vol 8, Iss 7, p e69413 (2013) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | B Cells, Mouse, Polymers, lcsh:Medicine, Lymphocyte Activation, Mice, 0302 clinical medicine, Receptors, Immunologic, lcsh:Science, Antigen Presentation, B-Lymphocytes, 0303 health sciences, Multidisciplinary, Animal Models, 3. Good health, medicine.anatomical_structure, Virus Diseases, Medicine, Research Article, Dendrimers, Ovalbumin, Immune Cells, T cell, Immunology, Antigen presentation, Antigen-Presenting Cells, Biology, Systemic Lupus Erythematosus, Antiviral Agents, Autoimmune Diseases, Proinflammatory cytokine, Immunomodulation, 03 medical and health sciences, Model Organisms, Immune system, Rheumatology, Phagocytosis, Antigen, medicine, Animals, Antigens, Cell Proliferation, 030304 developmental biology, Innate immune system, Lupus Erythematosus, lcsh:R, Histocompatibility Antigens Class II, Autoantibody, DNA, Dendrites, Immunity, Innate, Mice, Inbred C57BL, Antibody Formation, Nucleic acid, Clinical Immunology, lcsh:Q, Extracellular Space, 030215 immunology |
| الوصف: | Toll-like receptor (TLR) family members, 3, 7 and 9 are key components in initiation and progression of autoimmune disorders such as systemic lupus erythematosus (SLE). These TLRs are often referred to as nucleic acid-sensing TLRs based on their ability to recognize DNAs or RNAs produced by pathogens or damaged cells. During autoimmune disease progression these receptors recognize self nucleic acids as well as self nucleic acid-containing complexes and contribute to inflammatory cytokine production and subsequent enhancement of serum autoantibody levels. We have recently discovered that nucleic-acid scavenging polymers (NASPs) can neutralize the proinflammatory effects of nucleic acids. Here, we begin to explore what effects such NASPs have on normal immune function. We show that such NASPs can inhibit TLR activation without affecting nucleic acid-independent T cell activation. Moreover, we observe that stimulation of immune cells by encapsulated nucleic acids, such as those found in viral particles, is unaffected by NASPs. Thus NASPs only limit the activation of the immune system by accessible extra-cellular nucleic acid and do not engender non-specific immune suppression. These important findings suggest that NASPs represent a new approach toward anti-inflammatory drug development as these agents can potentially be utilized to block overt autoimmune disorders and inflammation while allowing normal immune responses to occur. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e550e066cbdcaa2e3057816d014479 http://europepmc.org/articles/PMC3720614?pdf=render |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....87e550e066cbdcaa2e3057816d014479 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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