Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: an ecological meta-regression
| العنوان: | Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: an ecological meta-regression |
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| المؤلفون: | Farshid Javdani, Naser Hatami, Alireza Sadeghinikoo, Ava Hosseini, Salma Ahi, Pouyan Keshavarz, Navid Kalani, Mostafa Fereydoni, Mahdi Foroughian |
| المصدر: | Endocrine |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Endocrinology, Diabetes and Metabolism, Pneumonia, Viral, 030209 endocrinology & metabolism, Disease, Peptidyl-Dipeptidase A, Renin-Angiotensin System, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Endocrinology, Gene Frequency, Diabetes mellitus, Genotype, medicine, Humans, Genetic Predisposition to Disease, Clinical significance, Meta-regression, Meta- Analysis, Letter to the Editor, Allele frequency, Pandemics, Polymorphism, Genetic, Ecology, business.industry, SARS-CoV-2, Mortality rate, COVID-19, medicine.disease, 030220 oncology & carcinogenesis, Meta-analysis, Angiotensin-Converting Enzyme 2, business, Coronavirus Infections |
| الوصف: | With the emergence of the Novel Coronavirus (2019-nCoV), researchers worldwide have started detecting the probable pathogenesis of the disease. The renin-angiotensin system (RAS) and angiotensin-converting enzymes have received a good deal of attention as possible pathways involved in 2019-nCoV pathogenesis. As the experiments seeking to find potential medications acting on these pathways are being conducted in the early phases, having an ecological worldview on the relationship between the prevalence of COVID-19 disease and the genetic differences in the genes involved in the RAS system could be valuable for the field. In this regard, we conducted a meta-analysis study of the prevalence of ACE (I/D) genotype in countries most affected by the COVID-19. In the meta-analysis, 48,758 healthy subjects from 30 different countries were evaluated in 116 studies, using the Comprehensive Meta-analysis software. The I/D allele frequency ratio was pooled by a random-effect model. The COVID-19 prevalence data of death and recovery rates were evaluated as the latitudes for the meta-regression analysis. Our results demonstrated that with the increase of the I/D allele frequency ratio, the recovery rate significantly increased (point estimate: 0.48, CI 95%: 0.05-0.91, p = 0.027). However, there was no significant difference in the case of death rate (point estimate: 1.74, CI 95%: 4.5-1.04, p = 0.22). This ecological perspective coupled with many limitations does not provide a direct clinical relevance between the COVID-19 and RAS system, but it shows potential pathophysiological associations. Our results raise concerns about ethnic and genetic differences that could affect the effectiveness of the currently investigated RAS-associated medications in different regions. |
| اللغة: | English |
| تدمد: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-020-02381-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ef1fcecefbbedacb6534ce7aa773f6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....87ef1fcecefbbedacb6534ce7aa773f6 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15590100 1355008X |
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| DOI: | 10.1007/s12020-020-02381-7 |